Formulation and Evaluation of Transdermal Film of Nitroglycerin
Keywords:Nitroglycerin, HPMC, Ethyl Cellulose, Cellulose Acetate Phthalate
The aim of the present study was to prepare and evaluate transdermal Films of Nitroglycerin using HPMC, Cellulose acetate phthalate, ethyl cellulose and Polypropylene glycol as a rate controlling membranes and HPMC, Cellulose acetate phthalate, ethyl cellulose as drug reservoir gels. Transdermal Films of Nitroglycerin with HPMC, Cellulose acetate phthalate, ethyl cellulose by varying the blend ratios were prepared by solvent casting method. The thickness medium range between 0.18 ± 0.02 mm to 0.22 ± 0.03mm whatever signifies that they’re military uniform in thickness. The customized formulation NF1 acquires stability reports for one to three months and the general films were tested for drug content and In-vitro diffusion.
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