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\def\citeauthor{~Venkata~Durga~Seshu~Priya~P,
              ~Ramesh~Babu~K,
              ~Bhanu~Prasad~Reddy~B,
              ~Suresh~K,
              ~Greeshma~N,
              ~Madhav,
              ~Venkatesh~P}
\def\citetitle{Formulation Development and Characterization of Glipizide Transdermal Gels by Using Permeation Enhancers}
\def\copyrightstmt{This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial- ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.}
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\def\RunningAuthor{Venkata Durga Seshu Priya P et al.}
\firstPage{155}
\articleType{Original Article}
\receivedDate{08 Jul 2021}
\acceptedDate{12 Aug 2021}
\revisedDate{11 Aug 2021}
\journalVolume{1}
\journalIssue{4}
\journalDoi{fjphs.v1i4.172}
\copyrightYear{2021}
\eISSN{2583-116X}
\journalDoi{fjphs.v1i4.172}
\def\authorCount{7}
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\def\journalTitle{Future Journal of Pharmaceuticals and Health Sciences}

\title{Formulation Development and Characterization of Glipizide Transdermal Gels by Using Permeation Enhancers}
\author{Venkata~Durga~Seshu~Priya~P\textsuperscript{*}\textsuperscript{1}\textsuperscript{\href{https://orcid.org/0000-0002-1023-6784}{\XeTeXLinkBox{\includegraphics[height=7pt]{orcid-logo-pharmascope.pdf}}}},  
            Ramesh~Babu~K\textsuperscript{2},  
            Bhanu~Prasad~Reddy~B\textsuperscript{3},  
            Suresh~K\textsuperscript{3},  
            Greeshma~N\textsuperscript{3},  
            Madhav\textsuperscript{3}, 
            Venkatesh~P\textsuperscript{3}~\\[5pt]{\textsuperscript{1}Department of Pharmaceutics, Jagan's Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M), Nellore-524346, SPSR Nellore (Dist), Andhra Pradesh, India}~\\{\textsuperscript{2}Department of Pharmaceutics, Swathi College of Pharmacy, NH5, Next to Nellore Toll Plaza, Venkatachalam, Nellore-524 320, SPSR Nellore (Dist), Andhra Pradesh, India}~\\{\textsuperscript{3}Jagan's Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M), Nellore-524346, SPSR Nellore (Dist), Andhra Pradesh, India}}

\begin{abstract}
That in research paper an effort were made to formulate glipizide transdermal patches using different permeation enhancers. The results obtained determined the polymer and solvent victimized had an influence on drug diffusion and permeability of the films. These results obtained showed that the drug diffusion via Eudragit RLPO films was relatively high compared to Eudragit RS100 and Eudragit RL100 films (Eudragit RLPO{\textgreater} Eudragit RL100{\textgreater} Eudragit RS100). The Formulation G6 has shown a good release. The effects designated to the nonionic surfactant Tween 20 expands the permeability qualities of Glipizide when compared to the other permeation modifiers.  
\end{abstract}\def\keywordstitle{Keywords}

\begin{keywords}Glipizide,\newline Transdermal Gels,\newline Permeation Enhancers,\newline Permeability Coefficient
\end{keywords}
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\makeatletter{\raggedright{\Large$^\ast$}Corresponding Author\par Name:\ Venkata~Durga~Seshu~Priya~P~\\ Phone:\ 9959523469~\\  Email:\ seshupriya09@gmail.com
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\section{Introduction}
In the present study, we aimed to deliver anti-diabetic drug glipizide for developing transdermal therapeutic systems for controlled release. Hence studies have been undertaken in the current study on membrane moderated therapeutic systems by using HPMC, CAP, ethylcellulose, and Polypropylene glycol as a rate-controlling membrane and HPMC, Cellulose acetate phthalate, ethylcellulose as drug reservoir gels. The manner of biosimilars is certain to avoid chronic disorders specified diabetics, which need longer-term dosing to take care of therapeutically drug concentration. The transdermal patch is used for anti-diabetic activity that belongs to the class sulfonylurea used for type 2 diabetes \unskip~\cite{1180351:22907162}.
    
\section{Materials and Methods}
Glipizide was received as free sample from Hetero Drugs Limited, Hyderabad. Eudragit RS 100, Eudragit RL 100, and Eudragit RLPO, Sodium CMC, Sodium alginate and Methylcellulose used to be acquired from SD fine chemicals Ltd., Mumbai. All abundant chemical as well as chemical agent utilized in this study are of analytical grade.

\textbf{Methodology}

\textbf{Drug-Excipients compatible studies}

Incase of polymer used in the formulation is in the dispersion forms instead of dispersion dry polymer whose dispersions are used in the formulation were kept under stability conditions \unskip~\cite{1180351:22907160}. 

\textbf{Preparation of drug-free films of Eudragit RS 100, Eudragit RL 100, and Eudragit RLPO Films}

The flicks were arranged by polymerizing the polymer in numerous solvents like Acetone, chloroform, dichloromethane, and ethyl acetate [Table~\ref{tw-92117e07d325}]. 

Dibutyl phthalate at a concentration of 15\% w/w of the polymer used to be used a plasticizer in the readying of films subsequent to 24 hours the dried fims give up out while stored in a desiccator \unskip~\cite{1180351:22907170}.

\textbf{Transdermal patch containing various permeation enhancers }

In a 100ml glass beaker polymer was added and made up with water and was allowed to soak for 24 hours and Glipizide 400 mg was weighed and added to the gel by dissolving in ethanol by titration inorder to get a homogenous dispersion. 

The permeation enhancers were incorporated by mixing with water. 

The gel was brimming in the collapsable tubes and labeled \unskip~\cite{1180351:22907169}.

\textbf{Composition of transdermal Patch Containing Various Permeation Enhancers (2\%)}

Here the optimized film and gel are taken and different compositions of the polymer enhancers are added and these were evaluated (Table~\ref{tw-a5e82c605027}, Table~\ref{tw-2ac838138f01} and Table~\ref{tw-221d171b4446}) \unskip~\cite{1180351:22907167}.

\textbf{Preparation of transdermal patch with different gel composition}

Here the optimized film and is taken and the different composition of gels are added to it and this composition was prepared and further evaluation (Table~\ref{tw-543264257f59}) \unskip~\cite{1180351:22907164}.

\textbf{Evaluation of Transdermal Films}

\textbf{Physical Appearance}

By apparent watching free films sort out have been evaluated (Table~\ref{tw-c0735aa56ca5}) \unskip~\cite{1180351:22907161}.

\textbf{Thickness uniformity}

It used to be sounded by screw gauge \unskip~\cite{1180351:22907161}. 

\textbf{Folding Endurance}

The no. of times the film that could be folded at the same place without breaking gave the exact value of folding endurance \unskip~\cite{1180351:22907168}.

\textit{\textbf{In-Vitro}} \textbf{ Skin Permeation }

\textit{In vitro} studies helps in identifying the mechanism of skin permeation of the drug and later it can be formulated into a transdermal therapeutic system \unskip~\cite{1180351:22907159}. 

\textbf{Kinetic Treatment}

The data obtained from the \textit{in vitro }dissolution studies acquire kinetic track record analysis \unskip~\cite{1180351:22907163}.

Zero-order kinetics: \textit{Q\ensuremath{_{t}} = Q\ensuremath{_{o}} + K\ensuremath{_{o}}t}

Korsmeyer-Peppas release model: \textit{Mt / M\ensuremath{_{\infty}}} \textit{ = K \ensuremath{\cdot} t \ensuremath{^{n}}}

\textbf{Permeability Coefficient}

From the drug diffusion data, it was calculated using the following equation (Table~\ref{tw-22f46f415650}, Table~\ref{tw-c4bb02c20dc6}, Table~\ref{tw-f0cb9e4a5177} and Table~\ref{tw-022113503bb0}) \unskip~\cite{1180351:22907166}.

$\style{font-family:'Times New Roman'}{\style{font-size:8px}{P_m=K_{app}.\frac HA}} $

Where, K\ensuremath{_{app}}= Diffusion rate constant (mg/h) calculated from the slope of the linear drug (d/p) diffusion profiles

 H = Thickness of the film (cm)

 A =Surfacearea of the film (cm\ensuremath{^{2}})

\textbf{Evaluation of Transdermal Gels}

\textbf{Drug content }

The Glipizide gel used to be liquefied in 50 ml of phosphate buffer (pH 7.4). spectacular absorbance was sounded after suitable dilution at 223 nm \unskip~\cite{1180351:22907171}. 

\textbf{pH and viscosity }

The pH of the dispersion was measured using a pH meter. Viscosity of the gels was determined using a Brook field rheometer \unskip~\cite{1180351:22907172}. 

\textbf{Extrudability }

It is the measurement of the flow ability of gels from tubes(collapsible). Comparison among the different formulations can be made regarding the effect of filling under various stress conditions and ease of extrusion. The results for all the formulations were recorded as extrusion pressure in grams \unskip~\cite{1180351:22907165}.

\textbf{Spreadability}

It was determined by an apparatus that consists of a wooden block provided with two glass slides. The lower slide was fixed on a wooden block and the upper slide with one end was tied to a glass slide and the other end tied to a weight pan. A gel quantity of 2.5g was placed between two slides and a 1000g weight was placed over it for 5 minutes to press the sample to a uniform thickness \unskip~\cite{1180351:22907173}.
    
\section{Results and Discussion}
In Physical observation of drug and excipients at the temperature of 40\ensuremath{^{o}}C/75\% RH there are no changes in White Crystalline Powder \& Free flow no aggregation (Table~\ref{tw-1881b9153ce2}).


\begin{table*}[!htbp]
\caption{\boldmath {Composition of Eudragit RS 100 RL100 \& RLPO Drug Free Films} }
\label{tw-92117e07d325}
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\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.20229999999999997\linewidth-2\tabcolsep}p{\dimexpr.08070000000000002\linewidth-2\tabcolsep}p{\dimexpr.07700000000000001\linewidth-2\tabcolsep}p{\dimexpr.07129999999999997\linewidth-2\tabcolsep}p{\dimexpr.06869999999999999\linewidth-2\tabcolsep}p{\dimexpr.06489999999999999\linewidth-2\tabcolsep}p{\dimexpr.064399999999999995\linewidth-2\tabcolsep}p{\dimexpr.0687\linewidth-2\tabcolsep}p{\dimexpr.06109999999999999\linewidth-2\tabcolsep}p{\dimexpr.0616\linewidth-2\tabcolsep}p{\dimexpr.05600000000000002\linewidth-2\tabcolsep}p{\dimexpr.059\linewidth-2\tabcolsep}p{\dimexpr.0643\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Ingredients & \cAlignHack F1 & \cAlignHack F2 & \cAlignHack F3 & \cAlignHack F4 & \cAlignHack F5 & \cAlignHack F6 & \cAlignHack F7 & \cAlignHack F8  & \cAlignHack F9  & \cAlignHack F10  & \cAlignHack F11  & \cAlignHack F12 \\
\tblmidrule 
\cAlignHack Eudragit RS100 \mbox{}\protect\newline (gm) &
  \cAlignHack 2 &
  \cAlignHack 2 &
  \cAlignHack 2 &
  \cAlignHack 2 &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack -  &
  \cAlignHack -  &
  \cAlignHack -  &
  \cAlignHack -  &
  \cAlignHack -  &
  \cAlignHack - \\
\cAlignHack Eudragit RL100 \mbox{}\protect\newline (gm) &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack 2 &
  \cAlignHack 2 &
  \cAlignHack 2  &
  \cAlignHack 2  &
  \cAlignHack -  &
  \cAlignHack --  &
  \cAlignHack -  &
  \cAlignHack - \\
\cAlignHack Eudragit RLPO \mbox{}\protect\newline (gm) &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack -  &
  \cAlignHack -  &
  \cAlignHack 2  &
  \cAlignHack 2  &
  \cAlignHack 2  &
  \cAlignHack 2 \\
\cAlignHack N-dibutyl phthalate (ml) &
  \cAlignHack 0.313 &
  \cAlignHack 0.313 &
  \cAlignHack 0.313 &
  \cAlignHack 0.313 &
  \cAlignHack 0.313 &
  \cAlignHack 0.313 &
  \cAlignHack 0.313  &
  \cAlignHack 0.313  &
  \cAlignHack 0.313  &
  \cAlignHack 0.313  &
  \cAlignHack 0.313  &
  \cAlignHack 0.313 \\
\cAlignHack Acetone (ml) &
  \cAlignHack 25 &
  \cAlignHack --- &
  \cAlignHack --- &
  \cAlignHack --- &
  \cAlignHack 25 &
  \cAlignHack --- &
  \cAlignHack ---  &
  \cAlignHack ---  &
  \cAlignHack 25  &
  \cAlignHack ---  &
  \cAlignHack ---  &
  \cAlignHack --- \\
\cAlignHack Dichloro-methane (ml) &
  \cAlignHack --- &
  \cAlignHack 25 &
  \cAlignHack --- &
  \cAlignHack --- &
  \cAlignHack --- &
  \cAlignHack 25 &
  \cAlignHack ---  &
  \cAlignHack ---  &
  \cAlignHack ---  &
  \cAlignHack 25  &
  \cAlignHack ---  &
  \cAlignHack --- \\
\cAlignHack Chloroform (ml) &
  \cAlignHack --- &
  \cAlignHack --- &
  \cAlignHack 25 &
  \cAlignHack --- &
  \cAlignHack --- &
  \cAlignHack --- &
  \cAlignHack 25  &
  \cAlignHack ---  &
  \cAlignHack ---  &
  \cAlignHack ---  &
  \cAlignHack 25  &
  \cAlignHack --- \\
\cAlignHack Ethyl acetate (ml) &
  \cAlignHack --- &
  \cAlignHack --- &
  \cAlignHack --- &
  \cAlignHack 25 &
  \cAlignHack --- &
  \cAlignHack --- &
  \cAlignHack ---  &
  \cAlignHack 25  &
  \cAlignHack ---  &
  \cAlignHack ---  &
  \cAlignHack ---  &
  \cAlignHack 25 \\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Composition of transdermal gels containing various polymers} }
\label{tw-a5e82c605027}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.3379\linewidth-2\tabcolsep}p{\dimexpr.09020000000000003\linewidth-2\tabcolsep}p{\dimexpr.1353\linewidth-2\tabcolsep}p{\dimexpr.1257\linewidth-2\tabcolsep}p{\dimexpr.1164\linewidth-2\tabcolsep}p{\dimexpr.11510000000000002\linewidth-2\tabcolsep}p{\dimexpr.079399999999999995\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Ingredients & \cAlignHack G1  & \cAlignHack G2  & \cAlignHack G3  & \cAlignHack G4  & \cAlignHack G5  & \cAlignHack G6 \\
\tblmidrule 
\cAlignHack Glipizide (mg) &
  \cAlignHack 400 &
  \cAlignHack 400 &
  \cAlignHack 400 &
  \cAlignHack 400 &
  \cAlignHack 400 &
  \cAlignHack 400\\
\cAlignHack Sodium CMC (mg) &
  \cAlignHack 900 &
  \cAlignHack -- &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack -\\
\cAlignHack Sodium Alginate (mg) &
  \cAlignHack - &
  \cAlignHack 1100 &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack -\\
\cAlignHack Methylcellulose (mg) &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack 800 &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack -\\
\cAlignHack HPMC (mg) &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack 1600 &
  \cAlignHack - &
  \cAlignHack -\\
\cAlignHack Sodium CMC: PVP (2.4cP) (1:1) (mg) &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack 900 &
  \cAlignHack -\\
\cAlignHack Sodium CMC: PEG6000 (1:1) (mg) &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack -- &
  \cAlignHack 900\\
\cAlignHack Alcohol (ml) &
  \cAlignHack 5 &
  \cAlignHack 5 &
  \cAlignHack 5 &
  \cAlignHack 5 &
  \cAlignHack 5 &
  \cAlignHack 5\\
\cAlignHack Distilled water (ml) &
  \cAlignHack 25 &
  \cAlignHack 25 &
  \cAlignHack 25 &
  \cAlignHack 25 &
  \cAlignHack 25 &
  \cAlignHack 25\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Composition of transdermal Patch Containing Permeation Enhancers} }
\label{tw-2ac838138f01}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.4322\linewidth-2\tabcolsep}p{\dimexpr.1286\linewidth-2\tabcolsep}p{\dimexpr.1271\linewidth-2\tabcolsep}p{\dimexpr.15030000000000001\linewidth-2\tabcolsep}p{\dimexpr.1618\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Ingredients & \cAlignHack GP1 & \cAlignHack GP2 & \cAlignHack GP3 & \cAlignHack GP4\\
\tblmidrule 
\cAlignHack Glipizide (mg) &
  \cAlignHack 400 &
  \cAlignHack 400 &
  \cAlignHack 400 &
  \cAlignHack 400\\
\cAlignHack Sodium CMC: PEG6000 (mg) (1:1) &
  \cAlignHack 950 &
  \cAlignHack 950 &
  \cAlignHack 950 &
  \cAlignHack 950\\
\cAlignHack Tween 20(ml) &
  \cAlignHack 0.361 &
  \cAlignHack -- &
  \cAlignHack - &
  \cAlignHack -\\
\cAlignHack SLS (mg) &
  \cAlignHack - &
  \cAlignHack 400 &
  \cAlignHack - &
  \cAlignHack -\\
\cAlignHack DMSO (ml) &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack 0.363 &
  \cAlignHack -\\
\cAlignHack PEG 400(ml) &
  \cAlignHack - &
  \cAlignHack - &
  \cAlignHack -- &
  \cAlignHack 0357\\
\cAlignHack Glycerin (ml) &
  \cAlignHack 2 &
  \cAlignHack 2 &
  \cAlignHack 2 &
  \cAlignHack 2\\
\cAlignHack Distilled water (ml) up to &
  \cAlignHack 20 &
  \cAlignHack 20 &
  \cAlignHack 20 &
  \cAlignHack 20\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Ingredients of Transdermal Patch with Permeation Enhancers} }
\label{tw-221d171b4446}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.3111\linewidth-2\tabcolsep}p{\dimexpr.1718\linewidth-2\tabcolsep}p{\dimexpr.1735\linewidth-2\tabcolsep}p{\dimexpr.1668\linewidth-2\tabcolsep}p{\dimexpr.1768\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Ingredients & \cAlignHack F12+GP1+ \mbox{}\protect\newline G6(P1) & \cAlignHack F12+GP2+ \mbox{}\protect\newline G6(P2) & \cAlignHack F12+GP3+ \mbox{}\protect\newline G6(P3) & \cAlignHack F12+GP4+ \mbox{}\protect\newline G6(P4)\\
\tblmidrule 
\cAlignHack Glipizide (mg) &
  \cAlignHack 400 &
  \cAlignHack 400 &
  \cAlignHack 400 &
  \cAlignHack 400\\
\cAlignHack Sodium CMC: PEG6000 (mg) (1:1) &
  \cAlignHack 950 &
  \cAlignHack 950 &
  \cAlignHack 950 &
  \cAlignHack 950\\
\cAlignHack Tween 20(ml) &
  \cAlignHack 0.361 &
  \cAlignHack --- &
  \cAlignHack --- &
  \cAlignHack ---\\
\cAlignHack SLS (mg) &
  \cAlignHack --- &
  \cAlignHack 400 &
  \cAlignHack --- &
  \cAlignHack ---\\
\cAlignHack DMSO (ml) &
  \cAlignHack --- &
  \cAlignHack --- &
  \cAlignHack 0.363 &
  \cAlignHack ---\\
\cAlignHack PEG 400(ml) &
  \cAlignHack --- &
  \cAlignHack --- &
  \cAlignHack --- &
  \cAlignHack 0357\\
\cAlignHack Glycerin (ml) &
  \cAlignHack 2 &
  \cAlignHack 2 &
  \cAlignHack 2 &
  \cAlignHack 2\\
\cAlignHack Distilled water (ml)  &
  \cAlignHack 20 &
  \cAlignHack 20 &
  \cAlignHack 20 &
  \cAlignHack 20\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Preparation of Glipizide Transdermal Patch Containing Gel} }
\label{tw-543264257f59}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.30240000000000002\linewidth-2\tabcolsep}p{\dimexpr.12919999999999998\linewidth-2\tabcolsep}p{\dimexpr.13310000000000002\linewidth-2\tabcolsep}p{\dimexpr.1055\linewidth-2\tabcolsep}p{\dimexpr.10100000000000001\linewidth-2\tabcolsep}p{\dimexpr.1185\linewidth-2\tabcolsep}p{\dimexpr.1103\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Ingredients & \cAlignHack F12+G1+GP1 \mbox{}\protect\newline (T1) & \cAlignHack F12+G2+ \mbox{}\protect\newline GP1 \mbox{}\protect\newline (T2)  & \cAlignHack F12+G3+ GP1 \mbox{}\protect\newline (T3)  & \cAlignHack F12+G+ GP1 \mbox{}\protect\newline (T4) & \cAlignHack F12+G5+ \mbox{}\protect\newline GP1 \mbox{}\protect\newline (T5) & \cAlignHack F12+G6+ GP1 \mbox{}\protect\newline (T6) \\
\tblmidrule 
\cAlignHack Glipizide (mg) &
  \cAlignHack 400 &
  \cAlignHack 400 &
  \cAlignHack 400 &
  \cAlignHack 400 &
  \cAlignHack 400 &
  \cAlignHack 400\\
\cAlignHack Sodium CMC(200-300cPs) (mg) &
  \cAlignHack 950 &
  \cAlignHack ---- &
  \cAlignHack ---- &
  \cAlignHack ---- &
  \cAlignHack ---- &
  \cAlignHack -----\\
\cAlignHack Sodium Alginate (mg) &
  \cAlignHack ---- &
  \cAlignHack 1200 &
  \cAlignHack ---- &
  \cAlignHack ----- &
  \cAlignHack ---- &
  \cAlignHack ----\\
\cAlignHack Methyl cellulose (28-32\%) (mg) &
  \cAlignHack ---- &
  \cAlignHack ---- &
  \cAlignHack 750 &
  \cAlignHack ---- &
  \cAlignHack ---- &
  \cAlignHack ----\\
\cAlignHack HPMC (50cPs) (mg) &
  \cAlignHack ---- &
  \cAlignHack ---- &
  \cAlignHack ---- &
  \cAlignHack 1750 &
  \cAlignHack ---- &
  \cAlignHack ----\\
\cAlignHack Sodium CMC: PVP (2.4cP) (1:1) (mg) &
  \cAlignHack ----- &
  \cAlignHack ---- &
  \cAlignHack ---- &
  \cAlignHack ---- &
  \cAlignHack 950 &
  \cAlignHack ---\\
\cAlignHack Sodium CMC: PEG6000 (1:1)(mg) &
  \cAlignHack ---- &
  \cAlignHack ---- &
  \cAlignHack ---- &
  \cAlignHack ---- &
  \cAlignHack ---- &
  \cAlignHack 950\\
\cAlignHack Alcohol (ml) &
  \cAlignHack 2 &
  \cAlignHack 2 &
  \cAlignHack 2 &
  \cAlignHack 2 &
  \cAlignHack 2 &
  \cAlignHack 2\\
\cAlignHack Distilled water (ml) up to &
  \cAlignHack 20 &
  \cAlignHack 20 &
  \cAlignHack 20 &
  \cAlignHack 20 &
  \cAlignHack 20 &
  \cAlignHack 20\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Drug - Excipient Compatibility Studies {\textendash} Physical Observation} }
\label{tw-c0735aa56ca5}
\centering 
\begin{threeparttable}

\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.29279999999999998\linewidth-2\tabcolsep}p{\dimexpr.12209999999999999\linewidth-2\tabcolsep}p{\dimexpr.11380000000000003\linewidth-2\tabcolsep}p{\dimexpr.14689999999999998\linewidth-2\tabcolsep}p{\dimexpr.3244\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Name of the sample & \cAlignHack Ratio & \multicolumn{3}{p{\dimexpr(.5851\linewidth-2\tabcolsep)}}{\cAlignHack Observation}\\
\rowcolor{kwdboxcolor}\cAlignHack  & \cAlignHack  & \cAlignHack Initial & \cAlignHack RT Initial & \cAlignHack 40\ensuremath{^{o}}C / 75\% RH (4 weeks)\\
\tblmidrule 
\cAlignHack API &
  \cAlignHack - &
  \cAlignHack ** &
  \cAlignHack ** &
  \cAlignHack **\\
\cAlignHack API + eudragit RS 100 &
  \cAlignHack 1:1.5 &
  \cAlignHack ** &
  \cAlignHack ** &
  \cAlignHack **\\
\cAlignHack API + RL 100 &
  \cAlignHack 1:1.5 &
  \cAlignHack ** &
  \cAlignHack ** &
  \cAlignHack **\\
\cAlignHack API + RLP0 &
  \cAlignHack 1:1.5 &
  \cAlignHack ** &
  \cAlignHack ** &
  \cAlignHack **\\
\cAlignHack API + HPMC &
  \cAlignHack 1:1.5 &
  \cAlignHack ** &
  \cAlignHack ** &
  \cAlignHack **\\
\cAlignHack API + Sodium alginate &
  \cAlignHack 1:1.5 &
  \cAlignHack ** &
  \cAlignHack ** &
  \cAlignHack **\\
\cAlignHack API + NACMC &
  \cAlignHack 1:1.5 &
  \cAlignHack ** &
  \cAlignHack ** &
  \cAlignHack **\\
\cAlignHack API +PVP6000 &
  \cAlignHack 1:1.5 &
  \cAlignHack ** &
  \cAlignHack ** &
  \cAlignHack **\\
\cAlignHack API + Methylcellulose &
  \cAlignHack 1:1.5 &
  \cAlignHack ** &
  \cAlignHack ** &
  \cAlignHack **\\
\tblbottomrule 
\end{tabulary}\par 
\begin{tablenotes}\footnotesize 
    
\item{** White Crystalline Powder. Free flow no aggregation}
\end{tablenotes}
\end{threeparttable}

\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Diffusion Data of Glipizide From Eudragit RS 100 Films} }
\label{tw-22f46f415650}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.16189999999999998\linewidth-2\tabcolsep}p{\dimexpr.23810000000000002\linewidth-2\tabcolsep}p{\dimexpr.20\linewidth-2\tabcolsep}p{\dimexpr.20\linewidth-2\tabcolsep}p{\dimexpr.20\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Time (h)  & \multicolumn{4}{p{\dimexpr(.8381\linewidth-2\tabcolsep)}}{\cAlignHack Amount of Glipizide Diffused (mg) (X\ensuremath{\pm} s d) }\\
\rowcolor{kwdboxcolor}\cAlignHack  & \multicolumn{4}{p{\dimexpr(.8381\linewidth-2\tabcolsep)}}{\cAlignHack Solvent Employed }\\
\rowcolor{kwdboxcolor}\cAlignHack  & \cAlignHack F1 & \cAlignHack F2 & \cAlignHack F3 & \cAlignHack F4\\
\tblmidrule 
\cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0\\
\cAlignHack 0.5 &
  \cAlignHack 0.915 \ensuremath{\pm} 0.05 &
  \cAlignHack 0.750 \ensuremath{\pm}0.05 &
  \cAlignHack 0.525 \ensuremath{\pm}0.05 &
  \cAlignHack 1.125 \ensuremath{\pm} 0.02\\
\cAlignHack 1 &
  \cAlignHack 1.816 \ensuremath{\pm}0.01 &
  \cAlignHack 1.490 \ensuremath{\pm}0.01 &
  \cAlignHack 1.025 \ensuremath{\pm}0.04 &
  \cAlignHack 2.280 \ensuremath{\pm} 0.02\\
\cAlignHack 1.5 &
  \cAlignHack 2.788 \ensuremath{\pm}0.04 &
  \cAlignHack 2.291 \ensuremath{\pm}0.02 &
  \cAlignHack 1.541 \ensuremath{\pm}0.02 &
  \cAlignHack 3.490 \ensuremath{\pm} 0.03\\
\cAlignHack 2 &
  \cAlignHack 3.817 \ensuremath{\pm}0.02 &
  \cAlignHack 3.124 \ensuremath{\pm}0.04 &
  \cAlignHack 2.117 \ensuremath{\pm}0.04 &
  \cAlignHack 4.773 \ensuremath{\pm} 0.05\\
\cAlignHack 2.5 &
  \cAlignHack 4.903 \ensuremath{\pm}0.02 &
  \cAlignHack 4.013 \ensuremath{\pm}0.02 &
  \cAlignHack 2.710 \ensuremath{\pm}0.07 &
  \cAlignHack 6.112 \ensuremath{\pm} 0.03\\
\cAlignHack 3 &
  \cAlignHack 6.061 \ensuremath{\pm}0.04 &
  \cAlignHack 4.944 \ensuremath{\pm}0.02 &
  \cAlignHack 3.349 \ensuremath{\pm}0.06 &
  \cAlignHack 7.566 \ensuremath{\pm} 0.02\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Permeability Coefficient of Glipizide From Eudragit RS 100 Films } }
\label{tw-c4bb02c20dc6}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.3341\linewidth-2\tabcolsep}p{\dimexpr.25750000000000004\linewidth-2\tabcolsep}p{\dimexpr.4084\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Polymer & \cAlignHack Casting solvent & \cAlignHack Permeability Coefficient\\
\rowcolor{kwdboxcolor} &  & \cAlignHack (PmX10\ensuremath{^{3}}  mg/cm.h)\\
\tblmidrule 
\multicolumn{1}{p{\dimexpr(.3341\linewidth-2\tabcolsep)}}{\multirow{4}{\linewidth}{\cAlignHack Eudragit RS100 Films}} &
  \cAlignHack F1 &
  \cAlignHack 1.5\\
 &
  \cAlignHack F2 &
  \cAlignHack 1.3\\
 &
  \cAlignHack F3 &
  \cAlignHack 0.8\\
 &
  \cAlignHack F4 &
  \cAlignHack 1.9\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Release order kinetics of glipizide from eudragit RS 100 films} }
\label{tw-fa0346b4af97}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.1434\linewidth-2\tabcolsep}p{\dimexpr.16830000000000002\linewidth-2\tabcolsep}p{\dimexpr.189\linewidth-2\tabcolsep}p{\dimexpr.1739\linewidth-2\tabcolsep}p{\dimexpr.2084\linewidth-2\tabcolsep}p{\dimexpr.117\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Solvents & \multicolumn{2}{p{\dimexpr(.35730000000000004\linewidth-2\tabcolsep)}}{\cAlignHack Correlation coefficient (r) values} & \cAlignHack Diffusion rate  & \cAlignHack Diffusion  & {\multirow{2}{*}{\cAlignHack T\ensuremath{_{50}}  (h)}}\\
\rowcolor{kwdboxcolor}\cAlignHack  & \cAlignHack Zero \mbox{}\protect\newline Order & \cAlignHack Peppas \mbox{}\protect\newline Model & \cAlignHack constant (k)  \mbox{}\protect\newline value (mg/h) \mbox{}\protect\newline  &
  \cAlignHack exponent  \mbox{}\protect\newline value (n) \mbox{}\protect\newline \\
\tblmidrule 
\cAlignHack F1 &
  \cAlignHack 0.998 &
  \cAlignHack 0.999 &
  \cAlignHack 2.011 &
  \cAlignHack 1.055 &
  \cAlignHack 4.973\\
\cAlignHack F2 &
  \cAlignHack 0.999 &
  \cAlignHack 0.999 &
  \cAlignHack 1.642 &
  \cAlignHack 1.052 &
  \cAlignHack 6.090\\
\cAlignHack F3 &
  \cAlignHack 0.999 &
  \cAlignHack 0.999 &
  \cAlignHack 1.108 &
  \cAlignHack 1.033 &
  \cAlignHack 9.025\\
\cAlignHack F4 &
  \cAlignHack 0.998 &
  \cAlignHack 0.999 &
  \cAlignHack 2.512 &
  \cAlignHack 1.061 &
  \cAlignHack 3.981\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Thickness and Folding endurance of Glipizide From Eudragit RL 100 Films} }
\label{tw-e25be79af044}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.25\linewidth-2\tabcolsep}p{\dimexpr.2521\linewidth-2\tabcolsep}p{\dimexpr.2479\linewidth-2\tabcolsep}p{\dimexpr.25\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Polymer & \cAlignHack Casting solvent & \cAlignHack Thickness (\ensuremath{\mu}m) & \cAlignHack Folding endurance\\
\tblmidrule 
\multicolumn{1}{p{\dimexpr(.25\linewidth-2\tabcolsep)}}{\multirow{4}{\linewidth}{\cAlignHack Eudragit RL100 }} &
  \cAlignHack F5 &
  \cAlignHack 34.40+0.65 &
  \cAlignHack 112\\
 &
  \cAlignHack F6 &
  \cAlignHack 37.80+0.37 &
  \cAlignHack 188\\
 &
  \cAlignHack F7 &
  \cAlignHack 36.80+0.15 &
  \cAlignHack 216\\
 &
  \cAlignHack F8 &
  \cAlignHack 37.60+0.28 &
  \cAlignHack 119\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Diffusion Data of Glipizide From Eudragit RL 100 Films} }
\label{tw-f0cb9e4a5177}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.13200000000000001\linewidth-2\tabcolsep}p{\dimexpr.20830000000000002\linewidth-2\tabcolsep}p{\dimexpr.2597\linewidth-2\tabcolsep}p{\dimexpr.20\linewidth-2\tabcolsep}p{\dimexpr.20\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Time (h) & \multicolumn{4}{p{\dimexpr(.868\linewidth-2\tabcolsep)}}{\cAlignHack Amount of Glipizide Diffused (mg) (X\ensuremath{\pm} s d)}\\
\rowcolor{kwdboxcolor}\cAlignHack  & \multicolumn{4}{p{\dimexpr(.868\linewidth-2\tabcolsep)}}{\cAlignHack Solvent Employed}\\
\rowcolor{kwdboxcolor}\cAlignHack  & \cAlignHack Acetone & \cAlignHack Dichloromethane & \cAlignHack Chloroform & \cAlignHack Ethyl Acetate\\
\tblmidrule 
\cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0\\
\cAlignHack 0.5 &
  \cAlignHack 1.050 \ensuremath{\pm} 0.05 &
  \cAlignHack 0.825 \ensuremath{\pm}0.05 &
  \cAlignHack 0.585 \ensuremath{\pm}0.05 &
  \cAlignHack 1.230 \ensuremath{\pm} 0.02\\
\cAlignHack 1 &
  \cAlignHack 2.125 \ensuremath{\pm}0.01 &
  \cAlignHack 1.240 \ensuremath{\pm}0.01 &
  \cAlignHack 1.149 \ensuremath{\pm}0.04 &
  \cAlignHack 2.467 \ensuremath{\pm} 0.02\\
\cAlignHack 1.5 &
  \cAlignHack 3.267 \ensuremath{\pm}0.04 &
  \cAlignHack 2.474 \ensuremath{\pm}0.02 &
  \cAlignHack 1.763 \ensuremath{\pm}0.02 &
  \cAlignHack 3.781 \ensuremath{\pm} 0.03\\
\cAlignHack 2 &
  \cAlignHack 4.476 \ensuremath{\pm}0.02 &
  \cAlignHack 3.410 \ensuremath{\pm}0.04 &
  \cAlignHack 2.410 \ensuremath{\pm}0.04 &
  \cAlignHack 5.202 \ensuremath{\pm} 0.05\\
\cAlignHack 2.5 &
  \cAlignHack 5.752 \ensuremath{\pm}0.02 &
  \cAlignHack 4.368 \ensuremath{\pm}0.02 &
  \cAlignHack 3.101 \ensuremath{\pm}0.07 &
  \cAlignHack 6.687 \ensuremath{\pm} 0.03\\
\cAlignHack 3 &
  \cAlignHack 7.110 \ensuremath{\pm}0.04 &
  \cAlignHack 5.391 \ensuremath{\pm}0.02 &
  \cAlignHack 3.823 \ensuremath{\pm}0.06 &
  \cAlignHack 8.280 \ensuremath{\pm} 0.02\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Permeability Coefficient Values of Glipizide From Eudragit RL 100 Films} }
\label{tw-7cb5bcf78f25}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.2221\linewidth-2\tabcolsep}p{\dimexpr.30509999999999994\linewidth-2\tabcolsep}p{\dimexpr.4728\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Polymer & \cAlignHack Casting & \cAlignHack Permeability coefficient\\
\rowcolor{kwdboxcolor} & \cAlignHack Solvent & \cAlignHack (pmx10\ensuremath{^{3}} mg/cm.h)\\
\tblmidrule 
\multicolumn{1}{p{\dimexpr(.2221\linewidth-2\tabcolsep)}}{\multirow{4}{\linewidth}{\cAlignHack Eudragit RL 100}} &
  \cAlignHack F5 &
  \cAlignHack 1.8\\
 &
  \cAlignHack F6 &
  \cAlignHack 1.4\\
 &
  \cAlignHack F7 &
  \cAlignHack 0.9\\
 &
  \cAlignHack F8 &
  \cAlignHack 2.1\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Correction Coefficient of Glipizide From Eudragit RL 100 Films} }
\label{tw-e947b5217f89}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.1406\linewidth-2\tabcolsep}p{\dimexpr.1794\linewidth-2\tabcolsep}p{\dimexpr.1821\linewidth-2\tabcolsep}p{\dimexpr.16139999999999997\linewidth-2\tabcolsep}p{\dimexpr.1946\linewidth-2\tabcolsep}p{\dimexpr.14190000000000001\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Solvent  & \multicolumn{2}{p{\dimexpr(.36150000000000006\linewidth-2\tabcolsep)}}{\cAlignHack Correlation Coefficient (R) Values} & \cAlignHack Rate Constant  & \cAlignHack Exponent Value & {\multirow{2}{*}{\cAlignHack T\ensuremath{_{50\ }}(H)}}\\
\rowcolor{kwdboxcolor}\cAlignHack  & \cAlignHack Zero \mbox{}\protect\newline Order & \cAlignHack Peppas \mbox{}\protect\newline Model & \cAlignHack Value (Mg/H) &
  \cAlignHack (N) \\
\tblmidrule 
\cAlignHack F5 &
  \cAlignHack 0.9989 &
  \cAlignHack 0.9996 &
  \cAlignHack 2.363 &
  \cAlignHack 1.066 &
  \cAlignHack 4.232\\
\cAlignHack F6 &
  \cAlignHack 0.9952 &
  \cAlignHack 0.9969 &
  \cAlignHack 1.816 &
  \cAlignHack 1.098 &
  \cAlignHack 5.507\\
\cAlignHack F7 &
  \cAlignHack 0.9989 &
  \cAlignHack 0.9994 &
  \cAlignHack 1.268 &
  \cAlignHack 1.047 &
  \cAlignHack 7.886\\
\cAlignHack F8 &
  \cAlignHack 0.9987 &
  \cAlignHack 0.9995 &
  \cAlignHack 2.749 &
  \cAlignHack 1.063 &
  \cAlignHack 3.638\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Thickness \& Folding Endurance of Eudragit RLPO Film} }
\label{tw-160487c8075c}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.1588\linewidth-2\tabcolsep}p{\dimexpr.27689999999999998\linewidth-2\tabcolsep}p{\dimexpr.26029999999999998\linewidth-2\tabcolsep}p{\dimexpr.30400000000000002\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Polymer & \cAlignHack Casting Solvent & \cAlignHack Thickness (\ensuremath{\mu}m) & \cAlignHack Folding Endurance\\
\tblmidrule 
\multicolumn{1}{p{\dimexpr(.1588\linewidth-2\tabcolsep)}}{\multirow{4}{\linewidth}{\cAlignHack Eudragit  \mbox{}\protect\newline RLPO}} &
  \cAlignHack F9 &
  \cAlignHack 36.60+0.15 &
  \cAlignHack 254\\
 &
  \cAlignHack F10 &
  \cAlignHack 37.60+0.14 &
  \cAlignHack 238\\
 &
  \cAlignHack F11 &
  \cAlignHack 37.20+0.13 &
  \cAlignHack 208\\
 &
  \cAlignHack F12 &
  \cAlignHack 38.00+0.14 &
  \cAlignHack 182\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Diffusion Data of Glipizide From Eudragit RLPO Films} }
\label{tw-23f98b2cb2a0}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.14519999999999998\linewidth-2\tabcolsep}p{\dimexpr.2681\linewidth-2\tabcolsep}p{\dimexpr.1867\linewidth-2\tabcolsep}p{\dimexpr.20\linewidth-2\tabcolsep}p{\dimexpr.20\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}{\multirow{3}{*}{\cAlignHack Time  \mbox{}\protect\newline (h) }} & \multicolumn{4}{p{\dimexpr(.8548\linewidth-2\tabcolsep)}}{\cAlignHack Amount of glipizide diffused (mg) (X\ensuremath{\pm} s d) }\\
\rowcolor{kwdboxcolor} & \multicolumn{4}{p{\dimexpr(.8548\linewidth-2\tabcolsep)}}{\cAlignHack Solvent Employed}\\
\rowcolor{kwdboxcolor} & \cAlignHack Acetone  & \cAlignHack Dichloromethane   & \cAlignHack Chloroform   & \cAlignHack Ethyl Acetate  \\
\tblmidrule 
\cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0\\
\cAlignHack 0.5 &
  \cAlignHack 1.155 \ensuremath{\pm} 0.05 &
  \cAlignHack 0.990 \ensuremath{\pm}0.05 &
  \cAlignHack 0.705 \ensuremath{\pm}0.05 &
  \cAlignHack 1.410 \ensuremath{\pm} 0.02\\
\cAlignHack 1 &
  \cAlignHack 2.327 \ensuremath{\pm}0.01 &
  \cAlignHack 1.986 \ensuremath{\pm}0.01 &
  \cAlignHack 1.382 \ensuremath{\pm}0.04 &
  \cAlignHack 2.854 \ensuremath{\pm} 0.02\\
\cAlignHack 1.5 &
  \cAlignHack 3.602 \ensuremath{\pm}0.04 &
  \cAlignHack 3.089 \ensuremath{\pm}0.02 &
  \cAlignHack 2.116 \ensuremath{\pm}0.02 &
  \cAlignHack 4.388 \ensuremath{\pm} 0.03\\
\cAlignHack 2 &
  \cAlignHack 4.952 \ensuremath{\pm}0.02 &
  \cAlignHack 4.227 \ensuremath{\pm}0.04 &
  \cAlignHack 2.878 \ensuremath{\pm}0.04 &
  \cAlignHack 6.012 \ensuremath{\pm} 0.05\\
\cAlignHack 2.5 &
  \cAlignHack 6.452 \ensuremath{\pm}0.02 &
  \cAlignHack 5.428 \ensuremath{\pm}0.02 &
  \cAlignHack 3.712 \ensuremath{\pm}0.07 &
  \cAlignHack 7.744 \ensuremath{\pm} 0.03\\
\cAlignHack 3 &
  \cAlignHack 7.777 \ensuremath{\pm}0.04 &
  \cAlignHack 6.677 \ensuremath{\pm}0.02 &
  \cAlignHack 4.575 \ensuremath{\pm}0.06 &
  \cAlignHack 9.546 \ensuremath{\pm} 0.02\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Correlation Coefficient of Glipizide From Eudragit RLPO Films} }
\label{tw-85eb9d7e46cc}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.1559\linewidth-2\tabcolsep}p{\dimexpr.1364\linewidth-2\tabcolsep}p{\dimexpr.21259999999999998\linewidth-2\tabcolsep}p{\dimexpr.2277\linewidth-2\tabcolsep}p{\dimexpr.1296\linewidth-2\tabcolsep}p{\dimexpr.13780000000000001\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}{\multirow{2}{*}{\cAlignHack Solvent \mbox{}\protect\newline Employed}} & \multicolumn{2}{p{\dimexpr(.349\linewidth-2\tabcolsep)}}{\cAlignHack Correlation Coefficient (R) Values} & \cAlignHack Rate Constant (K)  & \cAlignHack Exponent  & {\multirow{2}{*}{\cAlignHack T\ensuremath{_{50}}(h)}}\\
\rowcolor{kwdboxcolor} & \cAlignHack Zero Order & \cAlignHack Peppas Model & \cAlignHack Value (Mg/H) \mbox{}\protect\newline  &
  \cAlignHack Value (N) \mbox{}\protect\newline \\
\tblmidrule 
\cAlignHack F9 &
  \cAlignHack 0.9990 &
  \cAlignHack 0.9991 &
  \cAlignHack 2.611 &
  \cAlignHack 1.077 &
  \cAlignHack 3.829\\
\cAlignHack F10 &
  \cAlignHack 0.9990 &
  \cAlignHack 0.9996 &
  \cAlignHack 2.225 &
  \cAlignHack 1.067 &
  \cAlignHack 4.494\\
\cAlignHack F11 &
  \cAlignHack 0.9989 &
  \cAlignHack 0.9994 &
  \cAlignHack 1.517 &
  \cAlignHack 1.044 &
  \cAlignHack 6.592\\
\cAlignHack F12 &
  \cAlignHack 0.9989 &
  \cAlignHack 0.9997 &
  \cAlignHack 3.176 &
  \cAlignHack 1.067 &
  \cAlignHack 3.149\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Permeability Coefficient Values of Glipizide} }
\label{tw-3c98d09b076d}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.2719\linewidth-2\tabcolsep}p{\dimexpr.28230000000000004\linewidth-2\tabcolsep}p{\dimexpr.4458\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Polymer & \cAlignHack Casting Solvent & \cAlignHack PermeabilityCoefficient\\
\rowcolor{kwdboxcolor} &  & \cAlignHack (PmX10\ensuremath{^{3 }} mg/cm.h)\\
\tblmidrule 
\multicolumn{1}{p{\dimexpr(.2719\linewidth-2\tabcolsep)}}{\multirow{4}{\linewidth}{\cAlignHack Eudragit RLPO}} &
  \cAlignHack Acetone &
  \cAlignHack 2.00\\
 &
  \cAlignHack Dichloromethane &
  \cAlignHack 1.7\\
 &
  \cAlignHack Chloroform &
  \cAlignHack 1.2\\
 &
  \cAlignHack Ethyl Acetate &
  \cAlignHack 2.4\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Characteristics of gels formulated with different polymers} }
\label{tw-ed7906f48a0f}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.1988\linewidth-2\tabcolsep}p{\dimexpr.1613\linewidth-2\tabcolsep}p{\dimexpr.1572\linewidth-2\tabcolsep}p{\dimexpr.2111\linewidth-2\tabcolsep}p{\dimexpr.167\linewidth-2\tabcolsep}p{\dimexpr.1046\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Formulation  & \cAlignHack Drug content (\%) & \cAlignHack Viscosity  \mbox{}\protect\newline (cPs) & \cAlignHack Extrudabilit (N)  & \cAlignHack Spreadability  \mbox{}\protect\newline (g.cm/sec.)  & \cAlignHack pH \\
\tblmidrule 
\cAlignHack G1  &
  \cAlignHack 99.03  &
  \cAlignHack 1581  &
  \cAlignHack 14.91  &
  \cAlignHack 28.4  &
  \cAlignHack 7.12 \\
\cAlignHack G2  &
  \cAlignHack 98.48  &
  \cAlignHack 4776  &
  \cAlignHack 15.17  &
  \cAlignHack 31.64  &
  \cAlignHack 7.25 \\
\cAlignHack G3  &
  \cAlignHack 99.34  &
  \cAlignHack 1320  &
  \cAlignHack 15.66  &
  \cAlignHack 32.89  &
  \cAlignHack 7.16 \\
\cAlignHack G4  &
  \cAlignHack 99.49  &
  \cAlignHack 1570  &
  \cAlignHack 16.16  &
  \cAlignHack 29.76  &
  \cAlignHack 7.14 \\
\cAlignHack G5  &
  \cAlignHack 99.58  &
  \cAlignHack 2878  &
  \cAlignHack 15.41  &
  \cAlignHack 30.86  &
  \cAlignHack 7.26 \\
\cAlignHack G6  &
  \cAlignHack 99.19  &
  \cAlignHack 2634  &
  \cAlignHack 16.28  &
  \cAlignHack 30.12  &
  \cAlignHack 7.12 \\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Diffusion data of glipizide transdermal gels} }
\label{tw-022113503bb0}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.11860000000000001\linewidth-2\tabcolsep}p{\dimexpr.1531\linewidth-2\tabcolsep}p{\dimexpr.14120000000000001\linewidth-2\tabcolsep}p{\dimexpr.1471\linewidth-2\tabcolsep}p{\dimexpr.14\linewidth-2\tabcolsep}p{\dimexpr.1566\linewidth-2\tabcolsep}p{\dimexpr.1434\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\multicolumn{7}{p{\dimexpr(1\linewidth-2\tabcolsep)}}{\cAlignHack Amount of glipizide diffused(mg) X \ensuremath{\pm} s d}\\
\rowcolor{kwdboxcolor}\cAlignHack Time(h) & \cAlignHack T1 & \cAlignHack T2 & \cAlignHack T3 & \cAlignHack T4 & \cAlignHack T5 & \cAlignHack T6\\
\tblmidrule 
\cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0\\
\cAlignHack 0.5 &
  \cAlignHack 0.360\ensuremath{\pm}0.06 &
  \cAlignHack 0.330\ensuremath{\pm}0.06 &
  \cAlignHack 0.315\ensuremath{\pm}0.02 &
  \cAlignHack 0.285\ensuremath{\pm}0.03 &
  \cAlignHack 0.435\ensuremath{\pm}0.05 &
  \cAlignHack 0.495\ensuremath{\pm}0.03\\
\cAlignHack 1 &
  \cAlignHack 0.744\ensuremath{\pm}0.03 &
  \cAlignHack 0.682\ensuremath{\pm}0.08 &
  \cAlignHack 0.651\ensuremath{\pm}0.03 &
  \cAlignHack 0.574\ensuremath{\pm}0.05 &
  \cAlignHack 0.899\ensuremath{\pm}0.06 &
  \cAlignHack 1.008\ensuremath{\pm}0.06\\
\cAlignHack 1.5 &
  \cAlignHack 1.137\ensuremath{\pm}0.05 &
  \cAlignHack 1.041\ensuremath{\pm}0.05 &
  \cAlignHack 1.993\ensuremath{\pm}0.05 &
  \cAlignHack 0.896\ensuremath{\pm}0.06 &
  \cAlignHack 1.257\ensuremath{\pm}0.03 &
  \cAlignHack 1.433\ensuremath{\pm}0.05\\
\cAlignHack 2 &
  \cAlignHack 1.373\ensuremath{\pm}0.04 &
  \cAlignHack 1.226\ensuremath{\pm}0.03 &
  \cAlignHack 1.190\ensuremath{\pm}0.02 &
  \cAlignHack 1.057\ensuremath{\pm}0.04 &
  \cAlignHack 1.680\ensuremath{\pm}0.02 &
  \cAlignHack 2.972\ensuremath{\pm}0.09\\
\cAlignHack 2.5 &
  \cAlignHack 2.905\ensuremath{\pm}0.02 &
  \cAlignHack 1.584\ensuremath{\pm}0.01 &
  \cAlignHack 1.576\ensuremath{\pm}0.03 &
  \cAlignHack 1.345\ensuremath{\pm}0.03 &
  \cAlignHack 2.171\ensuremath{\pm}0.04 &
  \cAlignHack 2.511\ensuremath{\pm}0.04\\
\cAlignHack 3 &
  \cAlignHack 2.152\ensuremath{\pm}0.07 &
  \cAlignHack 1.916\ensuremath{\pm}0.02 &
  \cAlignHack 1.833\ensuremath{\pm}0.04 &
  \cAlignHack 1.603\ensuremath{\pm}0.04 &
  \cAlignHack 2.658\ensuremath{\pm}0.06 &
  \cAlignHack 3.078\ensuremath{\pm}0.07\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Correlation Coefficient of Glipizide From Various Transdermal Gels} }
\label{tw-0f8b7466a234}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.14620000000000001\linewidth-2\tabcolsep}p{\dimexpr.1738\linewidth-2\tabcolsep}p{\dimexpr.16\linewidth-2\tabcolsep}p{\dimexpr.1946\linewidth-2\tabcolsep}p{\dimexpr.15309999999999999\linewidth-2\tabcolsep}p{\dimexpr.1723\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Formulation & \multicolumn{2}{p{\dimexpr(.33379999999999995\linewidth-2\tabcolsep)}}{\cAlignHack Correlation coefficient (r) values} & \cAlignHack Rate constant (k) value (mg/h) & \cAlignHack Exponent value (n) & \cAlignHack T\ensuremath{_{50}}(h)\\
\rowcolor{kwdboxcolor}\cAlignHack  & \cAlignHack Zero \mbox{}\protect\newline Order & \cAlignHack Peppas \mbox{}\protect\newline Model &  &
   &
  \\
\tblmidrule 
\cAlignHack T1 &
  \cAlignHack 0.9976 &
  \cAlignHack 0.9982 &
  \cAlignHack 0.7268 &
  \cAlignHack 1.012 &
  \cAlignHack 13.759\\
\cAlignHack T2 &
  \cAlignHack 0.9982 &
  \cAlignHack 0.9979 &
  \cAlignHack 0.6286 &
  \cAlignHack 0.964 &
  \cAlignHack 15.908\\
\cAlignHack T3 &
  \cAlignHack 0.9985 &
  \cAlignHack 0.9984 &
  \cAlignHack 0.6114 &
  \cAlignHack 0.978 &
  \cAlignHack 16.3559\\
\cAlignHack T4 &
  \cAlignHack 0.9980 &
  \cAlignHack 0.9981 &
  \cAlignHack 0.5294 &
  \cAlignHack 0.955 &
  \cAlignHack 18.8893\\
\cAlignHack T5 &
  \cAlignHack 0.9992 &
  \cAlignHack 0.9991 &
  \cAlignHack 0.8734 &
  \cAlignHack 0.996 &
  \cAlignHack 11.4495\\
\cAlignHack T6 &
  \cAlignHack 0.9993 &
  \cAlignHack 0.9994 &
  \cAlignHack 1.0164 &
  \cAlignHack 1.010 &
  \cAlignHack 9.8386\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Permeability Coefficient Values of Glipizide From Various Transdermal Gels} }
\label{tw-3bcc8a80d66d}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.39\linewidth-2\tabcolsep}p{\dimexpr.61\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Formulation & \cAlignHack Permeability Coefficient\\
\rowcolor{kwdboxcolor} & \cAlignHack (PmX10\ensuremath{^{4 }} mg/cm.h)\\
\tblmidrule 
\cAlignHack T1 &
  \cAlignHack 5.59\\
\cAlignHack T2 &
  \cAlignHack 4.84\\
\cAlignHack T3 &
  \cAlignHack 4.708\\
\cAlignHack T4 &
  \cAlignHack 4.076\\
\cAlignHack T5 &
  \cAlignHack 6.725\\
\cAlignHack T6 &
  \cAlignHack 7.826\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Characteristics of gels formulated with different permeation enhancers} }
\label{tw-57113bfe8ee0}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.15016666666666667\linewidth-2\tabcolsep}p{\dimexpr.18316666666666666\linewidth-2\tabcolsep}p{\dimexpr.16666666666666668\linewidth-2\tabcolsep}p{\dimexpr.16666666666666668\linewidth-2\tabcolsep}p{\dimexpr.16666666666666668\linewidth-2\tabcolsep}p{\dimexpr.16666666666666668\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Formulation  & \cAlignHack Drug content (\%) & \cAlignHack Viscosity \mbox{}\protect\newline  (cPs) & \cAlignHack Extrudability \mbox{}\protect\newline  (N) & \cAlignHack Spreadability \mbox{}\protect\newline (g.cm/sec.) & \cAlignHack pH\\
\tblmidrule 
\cAlignHack GP1 &
  \cAlignHack 99.39 &
  \cAlignHack 1100 &
  \cAlignHack 15.89 &
  \cAlignHack 29.06 &
  \cAlignHack 7.32\\
\cAlignHack GP2 &
  \cAlignHack 99.54 &
  \cAlignHack 1673 &
  \cAlignHack 16.06 &
  \cAlignHack 32.05 &
  \cAlignHack 7.25\\
\cAlignHack GP3 &
  \cAlignHack 99.79 &
  \cAlignHack 1010 &
  \cAlignHack 15.74 &
  \cAlignHack 33.78 &
  \cAlignHack 7.14\\
\cAlignHack GP4 &
  \cAlignHack 99.97 &
  \cAlignHack 993 &
  \cAlignHack 16.46 &
  \cAlignHack 32.46 &
  \cAlignHack 7.23\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Diffusion Data of Glipizide From Transdermal Gels Containing Various Permeation Enhancers Through Eudragit RLPO Films} }
\label{tw-d618f5b91f83}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.21\linewidth-2\tabcolsep}p{\dimexpr.19\linewidth-2\tabcolsep}p{\dimexpr.20\linewidth-2\tabcolsep}p{\dimexpr.20\linewidth-2\tabcolsep}p{\dimexpr.20\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\multicolumn{5}{p{\dimexpr(1\linewidth-2\tabcolsep)}}{\cAlignHack Amount of glipizide diffused (mg) X \ensuremath{\pm} s d}\\
\rowcolor{kwdboxcolor}\cAlignHack Time (h) & \cAlignHack P1 & \cAlignHack P2  & \cAlignHack P3  & \cAlignHack P4 \\
\tblmidrule 
\cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0 &
  \cAlignHack 0\\
\cAlignHack 0.5 &
  \cAlignHack 0.405\ensuremath{\pm}0.02 &
  \cAlignHack 0.375\ensuremath{\pm}0.05 &
  \cAlignHack 0.345\ensuremath{\pm}0.05 &
  \cAlignHack 0.315\ensuremath{\pm}0.06\\
\cAlignHack 1 &
  \cAlignHack 0.822\ensuremath{\pm}0.06 &
  \cAlignHack 0.760\ensuremath{\pm}0.06 &
  \cAlignHack 0.698\ensuremath{\pm}0.03 &
  \cAlignHack 0.636\ensuremath{\pm}0.08\\
\cAlignHack 1.5 &
  \cAlignHack 1.160\ensuremath{\pm}0.05 &
  \cAlignHack 1.034\ensuremath{\pm}0.0 &
  \cAlignHack 1.968\ensuremath{\pm}0.09 &
  \cAlignHack 0.977\ensuremath{\pm}0.09\\
\cAlignHack 2 &
  \cAlignHack 1.562\ensuremath{\pm}0.07 &
  \cAlignHack 1.428\ensuremath{\pm}0.03 &
  \cAlignHack 1.298\ensuremath{\pm}0.02 &
  \cAlignHack 1.248\ensuremath{\pm}0.04\\
\cAlignHack 2.5 &
  \cAlignHack 2.001\ensuremath{\pm}60.06 &
  \cAlignHack 1.814\ensuremath{\pm}0.04 &
  \cAlignHack 1.661\ensuremath{\pm}0.04 &
  \cAlignHack 1.563\ensuremath{\pm}0.06\\
\cAlignHack 3 &
  \cAlignHack 2.433\ensuremath{\pm}0.02 &
  \cAlignHack 2.235\ensuremath{\pm}0.06 &
  \cAlignHack 2.013\ensuremath{\pm}0.06 &
  \cAlignHack 1.924\ensuremath{\pm}0.04\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Correlation coefficient of Glipizide From Transdermal Gels Containing Various Permeation Enhancers Through Eudragit RLPO Films} }
\label{tw-c024311c24d4}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.1476\linewidth-2\tabcolsep}p{\dimexpr.1724\linewidth-2\tabcolsep}p{\dimexpr.2291\linewidth-2\tabcolsep}p{\dimexpr.18219999999999995\linewidth-2\tabcolsep}p{\dimexpr.16690000000000005\linewidth-2\tabcolsep}p{\dimexpr.1018\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Formulation  & \multicolumn{2}{p{\dimexpr(.4015\linewidth-2\tabcolsep)}}{\cAlignHack Correlation coefficient (r) values} & \cAlignHack Rate constant  & \cAlignHack Exponent & {\multirow{2}{*}{\cAlignHack T\ensuremath{_{50}}(h)}}\\
\rowcolor{kwdboxcolor}\cAlignHack  & \cAlignHack Zero \mbox{}\protect\newline Order & \cAlignHack Peppas \mbox{}\protect\newline Model & \cAlignHack value (mg/h) \mbox{}\protect\newline (k)  &
  \cAlignHack value (n)\\
\tblmidrule 
\cAlignHack P1 &
  \cAlignHack 0.9995 &
  \cAlignHack 0.9993 &
  \cAlignHack 0.8022 &
  \cAlignHack 0.9905 &
  \cAlignHack 12.47\\
\cAlignHack P2 &
  \cAlignHack 0.9989 &
  \cAlignHack 0.9986 &
  \cAlignHack 0.7322 &
  \cAlignHack 0.9817 &
  \cAlignHack 13.66\\
\cAlignHack P3 &
  \cAlignHack 0.9994 &
  \cAlignHack 0.9992 &
  \cAlignHack 0.6622 &
  \cAlignHack 0.9717 &
  \cAlignHack 15.10\\
\cAlignHack P4 &
  \cAlignHack 0.9996 &
  \cAlignHack 0.9996 &
  \cAlignHack 0.6343 &
  \cAlignHack 1.001 &
  \cAlignHack 15.77\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Permeability coefficient values of glipizide from various transdermal gels containing various permeation enhancers through eudragit RLPO films} }
\label{tw-ca0c1530b2c3}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.4378\linewidth-2\tabcolsep}p{\dimexpr.5622\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Permeation Enhancers & \cAlignHack Permeability Coefficient\\
\rowcolor{kwdboxcolor} & \cAlignHack (Pmx10\ensuremath{^{4}}  Mg/Cm.H)\\
\tblmidrule 
\cAlignHack P1 &
  \cAlignHack 6.177\\
\cAlignHack P2 &
  \cAlignHack 5.638\\
\cAlignHack P3 &
  \cAlignHack 5.099\\
\cAlignHack P4 &
  \cAlignHack 4.884\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Physicochemical Properties of Gel (GP1) at 37\ensuremath{^{o}}C Temperature} }
\label{tw-1881b9153ce2}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.062\linewidth-2\tabcolsep}p{\dimexpr.158\linewidth-2\tabcolsep}p{\dimexpr.11\linewidth-2\tabcolsep}p{\dimexpr.11\linewidth-2\tabcolsep}p{\dimexpr.11\linewidth-2\tabcolsep}p{\dimexpr.11\linewidth-2\tabcolsep}p{\dimexpr.11\linewidth-2\tabcolsep}p{\dimexpr.11\linewidth-2\tabcolsep}p{\dimexpr.12\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack S.No & \cAlignHack Parameter & \cAlignHack 0 & \cAlignHack 1 & \cAlignHack 2 & \cAlignHack 3 & \cAlignHack 4 & \cAlignHack 5 & \cAlignHack 6\\
\tblmidrule 
\cAlignHack 1 &
  \cAlignHack Drug content (\%) &
  \cAlignHack 99.68 &
  \cAlignHack 99.40 &
  \cAlignHack 99.24 &
  \cAlignHack 99.08 &
  \cAlignHack 98.92 &
  \cAlignHack 98.76 &
  \cAlignHack 98.64\\
\cAlignHack 2 &
  \cAlignHack Viscosity (cps) &
  \cAlignHack 1085 &
  \cAlignHack 1079 &
  \cAlignHack 1072 &
  \cAlignHack 1069 &
  \cAlignHack 1064 &
  \cAlignHack 1058 &
  \cAlignHack 1051\\
\cAlignHack 3 &
  \cAlignHack pH &
  \cAlignHack 7.47 &
  \cAlignHack 7.45 &
  \cAlignHack 7.41 &
  \cAlignHack 7.39 &
  \cAlignHack 7.36 &
  \cAlignHack 7.32 &
  \cAlignHack 7.29\\
\cAlignHack 4 &
  \cAlignHack Spreadability (g.cm/sec) &
  \cAlignHack 29.46 &
  \cAlignHack 29.38 &
  \cAlignHack 29.34 &
  \cAlignHack 29.28 &
  \cAlignHack 29.26 &
  \cAlignHack 29.23 &
  \cAlignHack 29.21\\
\cAlignHack 5 &
  \cAlignHack Extrudability (N) &
  \cAlignHack 17.78 &
  \cAlignHack 17.67 &
  \cAlignHack 17.65 &
  \cAlignHack 17.62 &
  \cAlignHack 17.59 &
  \cAlignHack 17.55 &
  \cAlignHack 17.51\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}
All the films prepared were evaluated for thickness uniformity, folding endurance (Table~\ref{tw-e25be79af044} and Table~\ref{tw-160487c8075c}). Drug diffusion from these films was studied with 10 ml of 0.20\%W/V Glipizide solution by using Franz diffusion cell (Table~\ref{tw-fa0346b4af97} and Table~\ref{tw-23f98b2cb2a0}). The correlation coefficient values (r) were tabulated in Table~\ref{tw-e947b5217f89} and Table~\ref{tw-85eb9d7e46cc} consequently for Eudragit RS100, Eudragit RL100, and Eudragit RLPO. The diffusion exponent of release profiles (slope) for the polymer Eudragit RS100, RL100 AND RLPO has a value of 1.033-1.061; 1.047-1.093, and 1.044-1.077 respectively. Permeability coefficient values of the films towards the Glipizide (Table~\ref{tw-c4bb02c20dc6}, Table~\ref{tw-7cb5bcf78f25}, Table~\ref{tw-3c98d09b076d}, Table~\ref{tw-c024311c24d4} and Table~\ref{tw-ca0c1530b2c3}).

Gel formulations prepared with NaCMC, MC, and Na Alginate were found to be off-white and homogenous (Table~\ref{tw-ed7906f48a0f}). Drug content integrity of your formulations have been well in the range between 98.48-99.97 \%. The pH of all formulations have been around the skin pH 7.12 to 7.60 [Table~\ref{tw-57113bfe8ee0}]. It was well tried so the gel formulations displayed to good extrudability, and spreadability and the data (Table~\ref{tw-57113bfe8ee0}). The \textit{in-vitro } diffusion study of different gels across the Eudragit RLPO films prepared with Ethyl acetate (Table~\ref{tw-d618f5b91f83}). These values proved that the diffusion profiles follow zero-order kinetics and Peppas model (Table~\ref{tw-c024311c24d4} and Table~\ref{tw-ca0c1530b2c3}).
    
\section{CONCLUSION}
The current research indicated that the drug diffusion through Eudragit RLPO films was higher than Eudragit RS100and Eudragit RL100 films. Among all the films, Eudragit RLPO films prepared with Ethyl acetate proved high Permeability in comparison to abundant sort out films. These results indicated that the non-ionic surfactant Tween 20 improves the permeability characteristics of Glipizide compared to the opposite permeation enhancers used in the study.
    
\section{ACKNOWLEDGEMENTS}
The authors are thankful to the Secretary \& Correspondent (Mr. Madhu Sudhan Reddy) \& Principal (Dr. P. Venkatesh Sir) of Jagan's Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M) Nellore-524 346, SPSR Nellore (Dist) Andhra Pradesh for providing the necessary facilities to carry out this work.

\textbf{Conflict of Interest}

The authors attest that they have no conflict of interest in this study. 

\textbf{Funding Support}

No financial support for the current study.
    

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