Future Journal of Pharmaceuticals and Health Sciences

Targeted drug delivery to the lungs using mesoporous silica nanoparticles

Fri, 05 Apr 2024 00:00:00 +0530

Delivering drugs to tumour or defective cells effectively and efficiently while minimizing harmful side effects is one of the biggest issues facing the medical field. In order to address this issue, the pharmaceutical industry has developed a number of drug carriers that aid in getting the therapeutic medication or gene to the intended location. It has been discovered that mesoporous silica nanoparticles are biocompatible, chemically and thermally stable nanoparticles for this purpose the amount of research on MSNs has increased significantly in the last few years. Since 2001, when MCM-41 was first suggested as a drug carrier for a controlled delivery system, followed by SBA-15 and MCM-48. When changed, morphological features like pore size, pore volume, particle size, surface area, pH, and drug loading capacity have a significant impact on MSNs. Drug distribution to the intended place is elaborated by functionalizing MSNs with organic and inorganic groups. The most recent studies on MSN synthesis techniques and its uses in medical imaging, diagnostics, cellular uptake, target medication administration, cell tracing, and biosensing are also included in this review article.

Formulation and evaluation of nifedipine fast dissolving tablets

Syam Sundar Gurram, Nagaveni P, Sreevalli Arigela — Fri, 12 Apr 2024 00:00:00 +0530

The current study aims to formulate and evaluate the fast-dissolving tablet. The optimal concentration of Guar gum super disintegrate was found to be 20 mg, with a disintegration time of 27 seconds. This study assessed the disintegration time of tablets containing natural super disintegrant for the Disintegration test at various weight concentrations (6,8,10,12,14,16,18, and 20 mg). As a result, the Nifedipine fast dissolving tablets with Guar gum super disintegrant provide a quick therapeutic effect, a high dissolve rate, and a shorter disintegration time. In this study, the use of a natural (guar gum) super disintegrating agent increases the rate of dissolution as well as length of disintegration of fast-dissolving tablets. In vitro drug release of 96% is demonstrated in 6 minutes with a disintegrating efficiency of 27 seconds for Nifedipine FDTs (guar gum). Consequently, our study has shown that formulations made with a natural super disintegrating agent exhibit shorter disintegration times as well as higher rates of dissolution along with drug release.

Formulation and evaluation of hydrocortisone micro beads

Khaja Moinuddin Shaik, Pradeep Kumar M, Jagadeesh Babu B, Manjula C — Mon, 08 Apr 2024 00:00:00 +0530

The current study aimed to develop hydrocortisone mucoadhesive microbeads to prolong the drug's action in the gastrointestinal system, targeting Crohn's disease treatment. Hydrocortisone, known for its anti-inflammatory and anti-rheumatic effects, was utilized in bead form to enhance therapeutic efficacy, extend residence time, and reduce dosage frequency. Using sodium alginate, HPMC, and Eudragit L-100 as adhesive polymers, and calcium chloride and aluminium chloride as cross-linking agents, the study crafted microbeads with an entrapment efficiency between 57.23% and 91.69%. Evaluations focused on in vitro drug release, particle size, surface characteristics, entrapment efficiency, and the role of cross-linking ions. Of the formulations, HCS-8 (with sodium alginate and Eudragit L-100 using aluminium chloride as the gelling solution) and HCS-2 showed optimal drug release profiles. Notably, HCS-8 achieved a 12-hour drug release delay, attributed to aluminium chloride's cross-linking action. Drug release kinetics revealed a zero-order linearity (R2=0.99), suggesting super case 2 transport as the primary release mechanism.

In – Silico Biological Evaluation of Anticancer Drugs - SWISS ADME

Thu, 18 Apr 2024 00:00:00 +0530

The aim of the present work is to prepare anti-cancer drugs through In – Silico Biological Evaluation using SWISS ADME. The new Swiss ADME web tool, which includes in-house expert methods like the BOILED-Egg, Ilogp, and Bioavailability Radar, provides free access to a pool of quick yet reliable predictive models for physicochemical properties, pharmacokinetics, drug-likeness, and medicinal chemistry friendliness. It is developed to predict various pharmacodynamics and pharmacokinetics properties of small molecules, helping researchers in the drug discovery and development process. Researchers can use this tool to assess the potential success of a drug in terms of its ADME. Swiss ADME offers predictive model for various pharmacokinetic properties such as solubility, lipophilicity, and bioavailability this helps researchers assess how a drug candidate will be absorbed, distributed, metabolized, and excreted in the body.

Formulation and evaluation of pioglitazone microspheres

Rajagopal Rajaguru — Mon, 08 Apr 2024 00:00:00 +0530

The current study focuses on the formulation, development, and in vitro testing of pologlitazone microspheres containing guar gum and chitosan as naturally occurring polysaccharides that delay release. Nine formulations were created by altering the chitosan and guar gum ratios, using span-85 as an emulsifier as well as glutaraldehyde as a chemical cross linking agent. The microspheres were assessed in terms of particle size, encapsulation effectiveness, drug loading capacity, and in vitro drug release tests. The average particle size ranged from 30.2 mm (PP 1) to 36.5 mm (PP 2). There was a range of 0.45 to 0.78 in the swelling index. Microspheres smooth surfaces were found by SEM investigation. In order to verify that there are no chemical interactions between the medication and the polymer and to understand the structure of microspheres, differential scanning calorimetry as well as Fourier transform infrared spectroscopy were employed. At 10 hours, the optimised batch PP 1 released 97.45% using phosphate buffer pH7.4 as a dissolving media. In terms of release kinetics, the optimised formula's data were best fitted with the Higuchi model (r2= 0.671) and demonstrated zero order release (r2= 0.980) via a non-Fickian diffusion mechanism.

Formulation development and evaluation of acyclovir hard candy lozenges

Thu, 18 Apr 2024 00:00:00 +0530

Lozenges are dosage forms made of solid materials that are meant to dissolve or disintegrate gradually in the mouth. They are flavoured and sweetened to make them taste good, and they contain one or more active substances. Although its main purpose is topical, it may also contain substances with systemic effects. Preformulation studies are typically used to evaluate the physicochemical properties of drugs and determine their compatibility with other excipients. In this study five Acyclovir hard candy lozenges were prepared and the results of the FTIR spectrophotometry indicated that the drug and excipients employed in the formulation of the hard candy lozenges were compatible, as there were no interactions between the drug and the excipients as the peaks remained the same in the FTIR graphs. The manufactured medicated lozenges were tested for drug content homogeneity, hardness, thickness, weight variation, friability, moisture content, in vitro disintegration, as well as dissolution using pharmaceutical standard procedures. The drug concentration of the prepared lozenges ranged from 98.61 to 99.62 %. Among all the formulations F5, showed maximum drug release 100.23% at 35 minutes. Accelerated stability study conducted as per ICH guidelines (zone IV) at 45°C and 75% relative humidity for the best formulation F5 over a period of 30 and 60 days and was found that prepared formulation was stable.