Future Journal of Pharmaceuticals and Health Sciences http://pharmasprings.com/index.php/fjphs <p align="justify">The Future Journal of Pharmaceuticals and Health Sciences (FJPHS) sponsored by Pharma Springs Publications is established in the year 2020 with people from various avenues of the pharmacy profession. FJPHS is completely devoted to publications related to Pharmaceuticals and Health Sciences. FJPHS will be published quarterly per year in January, April, July, and October. The journal publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical Sciences and Allied sciences.</p> en-US editorpharmasprings@gmail.com (Editor) editorpharmasprings@gmail.com (Editor) Wed, 12 May 2021 00:00:00 +0000 OJS http://blogs.law.harvard.edu/tech/rss 60 A Glimpse of the Molecule Chalcone http://pharmasprings.com/index.php/fjphs/article/view/34 <p>The compound chalcone is very common which can available by synthetic means and naturally occurring from plant sources. These compounds have predominant value for their abundant properties with less adverse impacts on biological systems. The naturally occurring chalcone belongs to the flavonoid family. Chalcones are structural with two aromatic rings connected with three carbon ? &amp; ? unsaturated carbonyl systems. They possess many pharmacological activities like anti-inflammatory, antimalarial, antifungal, antileishmanial activities based on the substituents substituted on them. Benzene rings containing conjugated double bonds and completely delocalized ? electron system, molecules possessing this system have low redox potential and greater electron transfer reactions. This review article covers the chemistry, synthesis, biological activities, Isolation of natural or synthesized derivatives of chalcone. The main entity of this article is to summarize the expansion of this molecule related to the structural entities and pharmacological actions.</p> Monapati Suchitra, Sameera HR, Basavarajaiah NM Copyright (c) 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/index.php/fjphs/article/view/34 Wed, 12 May 2021 00:00:00 +0000 Conventional Opthalamic Drug Delivery System: An Outlook http://pharmasprings.com/index.php/fjphs/article/view/36 <p>The most sensitive and complex organ in the human body is the eye, so special attention should be needed for the administration of pharmaceutical substances into the eye. It is one of the most difficult for researchers in the preparation of drug delivery to the eye. The anatomical characteristics and physiological properties of the eye should be considered in drug delivery. The properties of pharmaceutical dosage forms depend upon the anatomy and physiology of the eye. Drug delivery on to the outer part as well as in the inner part of the ocular structure for the therapy is a unique and challenging one. Physiochemical, microbiological, and pharmaceutical properties lead to absorption and elimination of active therapeutic agents into and out of the eye. Loss of precorneal more and fastly occurs due to drainage in the region of extraocular are some of the drawbacks in ocular drug delivery of conventional dosage forms. To overcome these problems, advancements in conventional dosage forms take place.</p> Venkata Lokesh G, Madhuvani M, Chatla Chandana, Sarad Pawar Naik B, Bhargavi S, Manasa A Copyright (c) 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/index.php/fjphs/article/view/36 Wed, 12 May 2021 00:00:00 +0000 Role of COX-2 and ROS in UV-B Induced Skin Carcinogenesis http://pharmasprings.com/index.php/fjphs/article/view/46 <p>Non-melanoma skin tumors are among the cutaneous basal cell and squamous cell tumors (cSCCs), are the most predominant malignancies. While UV-stimulated p53 transformations give off an impression of being an early and essential occasion in the enhancement of skin tumors, another significant provider is the over-expression of cyclooxygenase-2 (COX-2). Oxidative pressures elevate with the moving inflammatory cells, are firmly related with cancer or malignant advancement, and have been demonstrated to be related with beginning, advancement, or movement measures during multistage carcinogenesis. UV generation of COX-2 illustration and Prostaglandin E2 (PGE2) creation is thought to advance skin carcinogenesis, as well as add up to even the most initial stages of UV-instigated skin damage. ROS (Reactive Oxygen Species) - intervened DNA injury assumes participation in the induction of carcinogenesis as well as in dangerous malignant alteration, and it might signify a significant donor in the pathogenesis of human carcinogenesis. The induction of COX-2 expression by acute UV exposure and constitutive up-regulation of COX-2 in UV-induced benign and malignant tumors leads to increased PGE2 production. ROS present inside the cells which are intracellular signaling cascades perform a function such as secondary messengers where they induce and maintain the oncogenic phenotype of cancer cells; however, cellular senescence and apoptosis can also be induced by ROS, and hence they also, therefore, function as anti-tumorigenic species.</p> Archana G, Kusu Susan Cyriac, Aliya Kouser N Copyright (c) 2021 http://pharmasprings.com/index.php/fjphs/article/view/46 Fri, 11 Jun 2021 00:00:00 +0000 Formulation and Characterization of Anti-Bacterial Activity of Silver Nanoparticles Using Root and Leaf of Wedelia trilobata http://pharmasprings.com/index.php/fjphs/article/view/37 <p>In the present study one such species, Wedelia trilobata, has be chosen to review the In vitro antibacterial activity of the root extract by using solvent ethanol for the selected plant Wedelia triolobata. The deduction of nanoparticles used to be unalterable by UV-Visible spectroscopy, FTIR, particle size, and zeta potential. The anti-bacterial activity of Wedelia trilobata mediated synthesis silver nanoparticles was tested by disc diffusion assay against standard organisms like Escherichia coli and staphylococcus aureus bacteria. The formation of silver nanoparticles by Wedelia trilobata was initially demonstrated by color changes confirmed by UV-Visible root exhibited a specific absorbance peak around 450 nm and leaf exhibited a specific absorbance peak around 418nm respectively. The Zeta potential of silver nanoparticles was found to be root 0.1 and leaf 0.4, so it indicates the dispersion and stability. The antibacterial activity against Gram-positive Staphylococcus aureus was increased, which was indicated by an increase in the inhibition zone diameter from 3Mm for normal (9.5Mm), standard (12.3Mm), control (11.3Mm), extraction for AgNPs Wedelia trilobata (13.8). 5Mm for normal (7.3Mm), standard (19.4Mm), control (10.5Mm), extraction for AgNPs Wedelia trilobata (19.8). The antibacterial activity against Gram-negative E.coli was increased, which was indicated by an increase in the inhibition zone diameter from 3Mm for normal (7.8Mm), standard (8.5Mm), control (10.2Mm), extraction for AgNPs Wedelia trilobata (14.3). 5Mm for normal (13Mm), standard (19.6Mm), control (15.3Mm) extraction for AgNPs Wedelia trilobata (19.8). The present investigation revealed that the ethanolic Root and aqueous leaf extracts the chosen plant have potential to suppress the expansion of infective bacterial strains.</p> Sai Prasanna K, Jyothi Reddy G, Kiran M, Appa Rao C Copyright (c) 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/index.php/fjphs/article/view/37 Tue, 20 Apr 2021 00:00:00 +0000 Formulation and Evaluation of Cimetidine In-Situ Gelling System By Factorial Design http://pharmasprings.com/index.php/fjphs/article/view/38 <p>The current papers offer the formulation, optimization, and evaluation of the starch-based in-situ gelling system of Cimetidine. The objective of the present study was to optimize the concentration of starch and concentration of MgCl<sub data-id="subscript-1">2</sub> for the formulation of in-situ gels of Cimetidine. Starch based in-situ gels of Cimetidine were subjected to measurement of viscosity, pH, drug content, and Q<sub data-id="subscript-2">80</sub>. Entirely the preliminary batches were prepared by using different concentrations of sodium alginate (0.5% - 2%) and a constant concentration of MgCl<sub data-id="subscript-3">2</sub>. On source the preliminary Screening, a 3<sup data-id="superscript-1">2</sup> full factorial pattern set about to review the consequence containing self-sustaining variables, Put concentration Containing starch (X<sub data-id="subscript-4">1</sub>) and concentration containing MgCl<sub data-id="subscript-5">2</sub> (X<sub data-id="subscript-6">2</sub>) as to apprenticed probabilities like viscosity, drug content, Q<sub data-id="subscript-7">80,</sub> and similarity factor. The best formulation C9 exhibited optimum viscosity (316 cp), drug content (99.25%), Q<sub data-id="subscript-8">80</sub> (90.15%), and similarity factor (73.46). The best batch exhibited good water uptake (62.44%) and there were no interactions were found during the IR study. A slow release of Cimetidine was observed and a good fit to the Korsmeyer Peppas plots was demonstrated. The correlation coefficient of the best batch is 0.9973 (Korsmeyer Peppas plots).</p> Bharath Kumar K R S C, Vijay Kumar Voleti, Dasthagiri Reddy Y, Madhusudhana Chetty C, Poluri Suresh, Naganjaneyulu R Copyright (c) 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/index.php/fjphs/article/view/38 Tue, 20 Apr 2021 00:00:00 +0000 Formulation and In-vitro Evaluation of Escitalopram Oxalate Tablets by Using Super Disintegrants http://pharmasprings.com/index.php/fjphs/article/view/39 <p>Oral disintegrating Escitalopram Oxalate tablets have been formulated by direct compressing method. Escitalopram Oxalate is used as antidepressant drug and is beneficial to somebody needing dysphagia. In compatibility report there is no interaction between the drug and also the polymers. The ET1-ET9 used to be developed through direct compressing method using super disintegrants croscarmellose sodium, Hydroxypropyl Cellulose and Polacrillin potassium. All the formulations showed good flow properties. The ET9 displayed to fine results as well as varied evaluation outcomes get pleasure from Hardness, Weight variation, Disintegration time, Drug content and Dissolution profile. Stability studies were carried out with optimized formulation ET9 which was stored for a period of one and two months at 40±2<sup>O</sup>C temperature and 75±5% relative humidity for a period 2 months. There are no changes in the values up to two months, it is a stable formulations.</p> Voleti Vijay Kumar, Bharath Kumar K R S C, Dasthagiri Reddy Y, Poluri Suresh, Naganjaneyulu R Copyright (c) 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/index.php/fjphs/article/view/39 Tue, 25 May 2021 00:00:00 +0000 RP-HPLC Method Designed for Determining Charantin in its Capsule Dosage Form http://pharmasprings.com/index.php/fjphs/article/view/47 <p>Charantin, a steroidal saponin found in the plant Momordica charantia and functions like insulin. It is combined with natural insulin, increasing insulin release and inhibiting gluconeogenesis. Charantin improves blood glucose levels by enhancing glucose absorption and glycogen synthesis in the liver, muscles, and fat cells, according to a large body of research. The great majority of the time, it is taken in the form of a capsule. Because of the increased availability of these newly released formulations, a new way of calculating the amount of medications included in the formulations is now required. The current work's RP-HPLC technique is aimed to estimate Charantin as well as confirm that Charantin is being calculated. The proposed RP-HPLC technology for assessing Charantin in capsule dosage form was found to be precise, specific, accurate, quick, and cost-effective. Label Claims (also known as labelling claims) are representations of the actual product attributes as stated on the product label. The sample recoveries from all formulations were consistent with their respective Label Claims, and this method is suitable for routine analysis. It is suitable for normal laboratory analysis and may be used to control the quality of raw materials, formulations, dissolution tests, and bioequivalence studies for the same formulation.</p> Manapati Jyothi, Varaprasad A, Vandana B, Nikitha G, Sandhya S, Sukanya U Copyright (c) 2021 http://pharmasprings.com/index.php/fjphs/article/view/47 Fri, 11 Jun 2021 00:00:00 +0000 Comparison of Process Parameter of Lab Batches, Scale-Up Batches Exhibit Batches Commercial Batches http://pharmasprings.com/index.php/fjphs/article/view/49 <p>The aim of the present work is to evaluate the critical process parameters and techniques and improve the quality and reduce cast and scaling up time. The pharmaceutical industry R &amp; D refers to the process of successful progress from drug discovery to product development. The need to the target market are identified alternative product concept are generated and evaluate and single concept of selected for future development. The concept is a description of the from function and features a product and a usefully. The Scale up is the process as define to increasing the batch size or increasing different physical parameter the output of volume. The old process scale up techniques doesn’t involve studying the critical process parameters (Raw Process). The scale up batches industry to improve quality of the product in moving from Scale up batches/Exhibit Batches and validation batches. To improve the batches quality scale up of a process Transformation of small scale lab batches into commercial scale depended on experience and probability and involving the more technique. Due to this probability of success is less understanding of critical process parameters and process enables control of critical step process parameter during manufacturing and successful transformation from lab scale to Exhibit batches and commercial batches.</p> Rajaguru R, Shalini G, Sai Priya R, Sutheesh T, Naveen Kumar P Copyright (c) 2021 http://pharmasprings.com/index.php/fjphs/article/view/49 Thu, 17 Jun 2021 00:00:00 +0000 Evaluation of Anti-Inflammatory Activity on Whole Plant of Aerva lanata (L.) by In-Vitro Methods http://pharmasprings.com/index.php/fjphs/article/view/50 <p>To evaluate the anti-inflammatory events of plant extracts going from A.lanata by In-vitro strategies.&nbsp; The main objectives of the proposed work is to evaluate anti-inflammatory utilization of aqueous (AQEAL) and alcoholic (ALEAL) extracts containing plant of Aerva lanata plant in different models of experimental. The Whole plant of A.lanata plant powder was made and extracted with 95% alcohol and water (maceration process) to get alcoholic (ALEAL) and aqueous (AQEAL). Preliminary phyto-chemical studies with AQEAL and ALEAL revealed sensational ubiquity of phytoconstitutents of both extracts. Both the extracts of whole plant of A.lanata&nbsp; had prevented protein denaturation against heat induced proteolysis.</p> Swathi Krishna K V, Likitha E, Benzawada Yaswantha, Chiramana Umakavya, Komaragiri Usha Sri, Mulumudi Suneel, Sumanth T, Vemuru Vamsi Copyright (c) 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/index.php/fjphs/article/view/50 Tue, 13 Jul 2021 00:00:00 +0000 Preparation and Characterization of Natural Face Pack http://pharmasprings.com/index.php/fjphs/article/view/51 <p>Herbal Products have huge demand from few decades as they yield good results without any side effects and provide a soothing effect for longer period of time. Using natural ingredients in a cosmetic formulation thus provides healthy and glowing skin. Currently, due to increase in pollution rate, skin allergic conditions, microbes and external effects human skin have become sensitive and prone to faster aging. Here we have made an attempt to formulate a pack ideal for all skin types. Thus, in the current work, the face packs that can be easily made with the available ingredients showed all the benefits and further optimization studies are necessary on various parameters to identify benefits on humans. The flow properties of natural herbal face pack show accurate results. All the ingredients were mixed homogenously and were evaluated for parameters like organoleptic properties (Appearance, color, odor, texture &amp; smoothness) particle size ranges from 23.5±2.15 ?m to 24.4±5.14 ?m, Ash content ranges from 86 ± 0.951 % to 94 ± 0.34 %, pH was ranges from 6.51 ± 0.12 to 6.65± 0.16. Loss on drying ranges from 3.18 % to 4.12 %. Irritancy tests, rheological features and stability. The obtained results showed that the prepared formulation was stable on all parameters. Irritancy test revealed negative. Stability tests showed the inertness of the formulation.</p> Jyoshna M, Surendra Babu S, Shaik Aliya, Syed Shahbaz Ali, Pradeep Kumar M Copyright (c) 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/index.php/fjphs/article/view/51 Tue, 13 Jul 2021 00:00:00 +0000 Formulation and Evaluation of Ketoprofen Emulgels by Model Independent Approach http://pharmasprings.com/index.php/fjphs/article/view/52 <p>In the current study, ketoprofen emulgels were prepared using Sodium CMC, Sodium alginate and Hibiscus as gelling agents in order to overcome gastric side effects and to achieve pharmacological response. Pre formulation parameters were performed to know the compatibility of pure drug ketoprofen with polymers CMC, Na alginate, hibiscus prior to the preparation of Emulgel. It indicates that no change was observed in the peak values of the drug in the physical mixture thus providing that both the drug and polymer were said to be compatible with each other. Emulgel of ketoprofen 2.5% w/w was prepared in 3 steps i.e., Preparation of gel, emulsion phases separately and incorporate both phases in homogenizer for a period of 45 min and stabilized it for 2 hrs. The prepared emulgels were evaluated for physical characteristics, drug content, pH, spreadability and in-vitro&nbsp; permeation studies. The physical appearance of all the formulations was creamy white, consistent, homogenous and stable. The pH of the prepared emulgels was found well within the range of 6-7. Release rate kinetics of the drug was studied with in vitro&nbsp; drug permeation data for all the formulations F1 to F9 and results were stated the best fit model for selected formulation F6 were found to be Zero order model with non-fickian diffusion. The formulations were compared with the reference product. The in-vitro dissolution of F6 was nearest to the reference product F10 (f2 = 85.17).</p> Venkata Durga Seshu Priya P, Ramesh Babu K, Raja Lakshmi S, Ramya B, Navin S, Harshitha V, Rupa B, Chandu Bhargav B Copyright (c) 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/index.php/fjphs/article/view/52 Tue, 13 Jul 2021 00:00:00 +0000