Future Journal of Pharmaceuticals and Health Sciences
http://pharmasprings.com/fjphs
<div> <img style="width: 100%;" src="https://pharmasprings.com/templates/frontend/pages/slideshow/slideshow.gif" /></div> <p align="justify">The Future Journal of Pharmaceuticals and Health Sciences (FJPHS) ISSN: 2583-116X sponsored by Pharma Springs Publication is established in the year 2021 with people from various avenues of the pharmacy profession. FJPHS is completely devoted to publications related to Pharmaceuticals and Health Sciences. FJPHS will be published quarterly. The journal publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical Sciences and Allied sciences.</p>Pharmasprings Publicationen-USFuture Journal of Pharmaceuticals and Health Sciences2583-116XFormulation and characterization: Metoprolol succinate controlled release matrix tablets
http://pharmasprings.com/fjphs/article/view/568
<p>Metoprolol succinate-controlled release matrix tablets were made utilizing the wet granulation process with various ratio of Hydroxypropyl methyl cellulose (HPMC K4M). Isopropyl alcohol is used as a granulating agent in the Povidone (PVP K30) solution. In addition to being utilised as diluents to raise the weight of the tablets, magnesium stearate and talc were added to enhance the granules' flow ability during tablet compression. The crushed tablets underwent physicochemical characteristics, in-vitro and kinetic tests, and the micromeritic properties of the generated granules were evaluated. In every formulation, results were nearly satisfactory, with M4 being the best among the others. All of the formulations showed good correlation. The drug diffusion kinetics from matrix tablets appeared to be zero order, and the release mechanism was diffusion regulated.</p>Alagusundaram MPriyanka KeshriPratibha SharmaNem Kumar JainChina Babu Dara
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2024-02-012024-02-0141899610.26452/fjphs.v4i1.568Formulation, Evaluation and Characterization of Hydrochlorothiazide Niosomes
http://pharmasprings.com/fjphs/article/view/566
<p>One of the many different carriers for getting a drug molecule to its site of action is a niosome, also known as a nonionic surfactant vesicle. Hydrophilic and hydrophobic medicines can both be trapped by them. The primary purpose of the medication hydrochlorothiazide, an angiotensin II type 1 receptor (AT1) antagonist, is to treat high blood pressure. Using cholesterol and nonionic surfactants (span 60) at varying concentrations, niosomes containing hydrochlorothiazide were created by the thin film hydration method. FTIR investigations, in vitro release studies, vesicular diameter, drug content, repeatability, shape and size distribution microphotography, and entrapment efficiency were all assessed for each niosome formulation.According to the findings, entrapment efficiency rises with surfactant concentration in all developed niosomal formulations. Low SD was found for the drug content, which ranged from 90.060.57 to 96.150.42. It was discovered that niosomes ranged in size from 0.280±0.098µm to 0.299±0.044µm and had a spherical shape. The medicine and formulation additives did not interact, according to the IR spectral analysis. Membrane diffusion cells were used to study the in vitro dissolution parameters. The findings indicate that formulation F6 exhibits a more controlled release action compared to the other formulation, with a 'n' value of 0.917, indicating that zero order kinetics were used to release the medication.</p>Ameer Pasha Shaik Vinod Naidu
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2024-02-012024-02-0141697910.26452/fjphs.v4i1.566Screening of important factors using factorial design to predict simvastatin loaded solid lipid nanoparticles
http://pharmasprings.com/fjphs/article/view/581
<p>This study aims to optimize Simvastatin-loaded Solid Lipid Nanoparticles (SLNs) using a 2^k factorial design approach. Simvastatin, a widely used cholesterol-lowering drug, faces bioavailability challenges, prompting the use of nanotechnology for drug delivery. The study focuses on lipid concentration, surfactant concentration, and homogenization speed as critical factors influencing SLN characteristics. These factors were chosen based on their potential impact on SLN physicochemical properties like particle size, polydispersity index, and drug entrapment efficiency. Through systematic variation of factor levels, a matrix of experiments will be created, measuring responses (particle size, polydispersity index, and drug entrapment efficiency) for each run. Statistical analysis, including ANOVA, will assess factor significance and interactions. The study aims to reveal critical parameters affecting Simvastatin-loaded SLN formulation. The optimized formulation targets uniform and stable nanoparticles with enhanced drug entrapment, enhancing Simvastatin bioavailability. The factorial design method offers a systematic, resource-efficient approach for simultaneously screening and optimizing multiple factors, streamlining the experimental process.Top of Form</p>Bhaskar Reddy KesavanAudi Narayana NelavalaSoujanya G S
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2024-02-092024-02-09419710110.26452/fjphs.v4i1.581A Prospective Observational Study in a Tertiary Care Teaching Hospital on the Trends and Outcomes of Poisoning Cases
http://pharmasprings.com/fjphs/article/view/551
<p>Developing countries suffer from significant morbidity and mortality making poisoning the global health problem with thousands of deaths occurring every year. In India, 70% of the land is occupied by Agriculture making farmers the worst affected which accounts for one-third of pesticide poisoning. Organophosphorus chemicals as well as purposeful self-ingestion of poison in an effort at suicide account for the majority of the significant burden of poisoning associated with morbidity and mortality. Enforcing the law correctly when it comes to the distribution and sale of addictive medications, establishing boundaries for electronic media when it comes to exposing people to harsh facts and raising societal awareness of the importance of education are essential objectives. Not only will it save countless lives, but it will also lower health budget costs by fighting and managing diseases in line with WHO targets in poor nations.</p>Chandu LalithaPenabaka Venugopalaiah
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2024-01-132024-01-1341394510.26452/fjphs.v4i1.551Formulation and evaluation of moxifloxacin loaded ocular In-situ gels
http://pharmasprings.com/fjphs/article/view/559
<p>Moxifloxacin, a fourth-generation broad-spectrum antibiotic, is at the heart of this research, aimed at treating infective ophthalmitis through sustained release via ion-sensitive ocular in-situ gels. The study emphasizes the importance of careful polymer and drug selection for effective oral in-situ gel formulation. Sodium alginate and HPMC were identified as compatible polymers with Moxifloxacin, as confirmed by IR and UV analyses. The concentration of these polymers significantly influences the gel's viscosity, spreadability, and drug release properties. Among the tested formulations, F4 emerged as superior, exhibiting the highest drug release and favorable rheological properties. This formulation not only showed good stability and uniformity but also resulted in better and faster patient improvement. Although the current results are promising, further pharmacokinetic studies are suggested. The F4 formulation outperformed others in efficacy, making it the most optimal choice. In vitro release studies validated the effectiveness of the Moxifloxacin gel formulations used in this research. The extended drug delivery system developed here has the potential to enhance the bioavailability of the medication, thereby improving patient efficacy, compliance, and overall therapeutic value.</p>Sirisha VelchuriRam Babu PSandeep Kumar GRevathi Sarvepalli
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2024-01-282024-01-2841516010.26452/fjphs.v4i1.559Unveiling the Secrets of Bougainvillea: A Review of Phytochemical and Pharmacological Properties
http://pharmasprings.com/fjphs/article/view/586
<p>This review dives into the fascinating world of Bougainvillea, exploring its chemical makeup and potential health benefits. While research encompasses 18 species, most studies (phytochemical, pharmacological, and toxicological) have focused on just four species and their cultivars, along with one hybrid. Interestingly, some Bougainvillea species already have a history of use in traditional medicine. Scientific investigations have confirmed the presence of diverse chemical compounds within Bougainvillea, including aliphatic hydrocarbons, fatty acids, volatile oils, phenolics, flavonoids, and terpenes. These studies suggest that not only the extracts but also isolated active components from Bougainvillea exhibit a wide range of pharmacological activities. This exciting potential pave the way for further exploration of Bougainvillea as a source of valuable therapeutic compounds. To unlock the full potential of Bougainvillea, future research should delve deeper into the phytochemical, pharmacological, and toxicological properties of all species, cultivars, and hybrids. Understanding mechanisms of action, safety, and efficacy is crucial for responsible development of any potential medications derived from this beautiful and promising genus.</p>Nagashubha BobbarjangUma Maheshwara Rao VIswarya SKarishma PNMythri GTariq Ahmad KhariMohammed Akram GSCharitha BKiran Sai Maccha
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2024-03-072024-03-074111012210.26452/fjphs.v4i1.586An expatiate review on adjuvant chemotherapy of colorectal cancer
http://pharmasprings.com/fjphs/article/view/567
<p>Colorectal cancer is the second leading cause of cancer-related death and the third most common cancer globally. For loco regional colon cancer, surgery is the sole curative option. Adjuvant chemotherapy aims to eliminate micro metastases and increase survival. It has been most convincingly proven in stage III illness, even though there is ongoing debate on the usefulness of adjuvant chemotherapy for stage II illness. For the past fifteen years, six months of adjuvant chemotherapy with an oxaliplatin-based chemotherapy has been the accepted standard of care for stage III colon cancer. It is still advised to use 6 months of adjuvant chemotherapy for individuals with stage II illness and high clinicopathological risk. Chemo radiation therapy (CRT) is frequently used as neoadjuvant or adjuvant therapy in the treatment of stage II and stage III rectal cancers because this cancer type has a higher risk of local recurrence than other cancer types.</p>Shahireen ShahireenVipplavi Eka Kavya Rachamsetty Dhachinamoorthi Duraiswamy Rama Chandra Reddy L
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2024-02-012024-02-0141808810.26452/fjphs.v4i1.567Metformin hydrochloride: The most prescribed treatment for type II diabetes -gets banned
http://pharmasprings.com/fjphs/article/view/585
<p>Metformin hydrochloride (MH) is synthesis of N, N-dimethylguanidine medicament which is used for the treat of type-II diabetes which was discovered by Emil Werner and James Bell, which belongs to BCS class III. MH is chosen first-line oral blood glucose-lowering medication for the treatment of type-II diabetes, almost around 120 million patients are using worldwide. It works by decreasing the hepatic glucose production through a mild inhibition of mitochondrial respiration chain complex. MH which has been further tested and also proven that it can be used for various treatments such as, weight loss, improving fertility, slow the growth of tumour, anti-malaria, and few others. MH is synthesis from Galega officinalis which is a perennial plant that blooms in the summer and is native to most temperate areas. In this study, complete information about the drug history, drug profile, pharmacokinetic, drug interaction, clinical symptoms, advantages & disadvantages of MH and reason why its getting banned has been explained in detail.</p>Joan Vijetha RKaviyarasan KAnnie Bhuvana Mary AGopinath NSam Daniel JVasanth B
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2024-03-072024-03-074110210910.26452/fjphs.v4i1.585Comprehensive Review of Oro Dispersible Tablets and Co Processed Super disintegrants
http://pharmasprings.com/fjphs/article/view/548
<p>Due to their ease of administration, self-administration, and improved patient compliance, solid dosage forms are most popular. The most normally utilized strong dose structures are tablets and capsules, which is challenging for pediatric and geriatric patients. Considering these prerequisites endeavors have been made to foster rapid dissolving Tablets. The solid dosage form of a medicine that dissolves in a matter of seconds when swallowed is known as orodispersible tablet. The utilization of Superdisintegrants improves the crumbling season of the tablet. Fast Dissolving Tablets are generally liked because of their convenience, higher bioavailability, quick disintegration and breaking down of the medication. The various technologies utilized in the formulation of Orodispersible tablets (ODT) and their evaluation are the primary focus of this review.</p>Voleti Vijaya Kumar Nandhini MSreelekhaa TPraveen AE. Saravana KumarSrinath MVishwa SShanmugapandiyan P
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2024-01-132024-01-134111310.26452/fjphs.v4i1.548A comprehensive review on pilot plant scale up and platform technology
http://pharmasprings.com/fjphs/article/view/549
<p>The pharmaceutical business uses pilot plant scale-up strategies to create reliable manufacturing procedures and turn lab-scale formulas into commercial products. The place called Pilot is where the five elements Material, Man, Method, and Machine are combined to manufacture things. A tiny, basic lab scale formula will be tested on a replica of the intended plant in the pilot plant before spending a significant amount of money on a production unit. Scaling up a pilot plant provides information on formula examination, reviewing the range of pertinent processing equipment, understanding raw material specifications, production rate, and physical space requirements. It can hold accurate documentation and reports for analysis in support of the GMP procedure. This review research discusses the factors for solids, liquids, and semisolids for scaling up pilot plants. The primary goal of a pilot plant is to "identify errors on a small scale and generate revenue on a large scale."</p>Kishore BandarapalleRajasekhar Komarla KumarachariKamasani Teja SriBoyalapalli NeerajaChejarla LikhithaKrishna ChaitanyaC Y Bhargavi
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2024-01-132024-01-1341142510.26452/fjphs.v4i1.549A Review on regulatory affairs and regulatory requirements for drug approval
http://pharmasprings.com/fjphs/article/view/550
<p>Regulatory affairs are a new profession that can be developed for the controlling the safety, quality and efficacy of the drug products by submitting the investigational new drug application (IND) and new drug application (NDA) to regulatory authority. The whole process may be done in conscious manner in order to release a safe drug product to protect the public from toxic effects of drugs during and after the usage of drugs. The main intention of this article was to aware the peoples towards the role of regulatory affairs department, requirements for new drug approval and the involvement of the regulatory professionals in this process as well as how crucial it is to perform and monitor the clinical and nonclinical trials of the drug before marketing the drug.</p>Kishore BandarapalleRajasekhar Komarla KumarachariKamasani Teja SriBoyalapalli NeerajaChejarla LikhithaKrishna ChaitanyaC Y Bhargavi
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2024-01-132024-01-1341263810.26452/fjphs.v4i1.550Unravelling framework for herbal product manufacturing and approval in south India
http://pharmasprings.com/fjphs/article/view/552
<p>This study investigates the regulatory framework for manufacturing and approving herbal products in South India, a region with increasing global demand for natural remedies. It focuses on understanding the specific guidelines and processes crucial for industry stakeholders and regulatory authorities. The research highlights the unique aspects of the South Indian regulatory environment, including botanical authenticity, safety assessments, labeling requirements, and the protection of traditional knowledge. The aim is to assist manufacturers, regulators, and policymakers in ensuring the quality, safety, and efficacy of herbal products. Methodologically, the study relies on document analysis, expert interviews, and case studies of approved herbal products. Its findings aim to enrich the understanding of herbal product regulation, promoting sustainable development and trade in this field. This research is a valuable asset for industry professionals, researchers, and policymakers in the herbal products sector. Keywords: Herbal products, regulatory framework, South India, traditional knowledge, safety assessments, authenticity. (160 words).</p>A RajiniD JothieswariS Ranjitha NN Audi Narayana
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2024-01-132024-01-1341465010.26452/fjphs.v4i1.552Virtue of methotrexate in ectopic pregnancy
http://pharmasprings.com/fjphs/article/view/563
<p>In recent times there is a shortfall of care about ectopic pregnancy among everyone, inciting conceded finding and potentially non -violent results. Ectopic pregnancy is a very dangerous medical disorder. This occurs when a fertilised egg implants outside of the uterus, generally in the fallopian tube. Making up 5%–10% of all pregnancy-related deaths, ectopic pregnancies are the leading cause of maternal death in the first trimester. Methotrexate is a folic acid inhibitor. It interferes with DNA synthesis and cell multiplication by inhibiting the spontaneous synthesis of purines and pyrimidines. Methotrexate will be used in the middle of six and eight weeks of pregnancy. The likelihood of a future pregnancy succeeding after using methotrexate is generally positive, according to studies. However, a few things could have an impact on these odds. As per to research, ectopic pregnancies are more common among women of reproductive age, usually between the ages of 20 and 35. Given that they are more likely to be sexually active and trying to get pregnant, women in this age range are at their most fertile. Additionally, the prevalence of sexually transmitted diseases (STIs) is higher in this age group, which can mark up the chance of an ectopic pregnancy. Factors affecting ectopic pregnancy risk include previous pelvic surgeries, infections, in vitro fertilization [IVF], endometriosis, smoking, assisted reproductive technologies, and tubal sterilization or previous pregnancies. This review of the literature attempts to shed insight on how methotrexate is currently used to treat ectopic pregnancies</p>Salma Shaik Lakshmi Manasa Venkata Sai Kavya RachamsettyDhachinamoorthi Duraiswamy Rama Chandra Reddy L
Copyright (c) 2024 Future Journal of Pharmaceuticals and Health Sciences
2024-01-282024-01-2841616810.26452/fjphs.v4i1.563