Formulation and Evaluation of Ketoprofen Emulgels by Model Independent Approach

Authors

  • Venkata Durga Seshu Priya P Department of Pharmaceutics, Jagan’s Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M), Nellore-524346, SPSR Nellore (Dist) Andhra Pradesh, India
  • Ramesh Babu K Department of Pharmaceutics, Swathi College of Pharmacy, NH5, Next to Nellore Toll Plaza, Venkatachalam, Nellore-524 320, SPSR Nellore (Dist), Andhra Pradesh, India
  • Raja Lakshmi S Jagan’s Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M), Nellore-524346, SPSR Nellore (Dist), Andhra Pradesh, India
  • Ramya B Jagan’s Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M), Nellore-524346, SPSR Nellore (Dist), Andhra Pradesh, India
  • Navin S Jagan’s Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M), Nellore-524346, SPSR Nellore (Dist), Andhra Pradesh, India
  • Harshitha V Jagan’s Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M), Nellore-524346, SPSR Nellore (Dist), Andhra Pradesh, India
  • Rupa B Jagan’s Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M), Nellore-524346, SPSR Nellore (Dist), Andhra Pradesh, India
  • Chandu Bhargav B Jagan’s Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M), Nellore-524346, SPSR Nellore (Dist), Andhra Pradesh, India

Abstract

In the current study, ketoprofen emulgels were prepared using Sodium CMC, Sodium alginate and Hibiscus as gelling agents in order to overcome gastric side effects and to achieve pharmacological response. Pre formulation parameters were performed to know the compatibility of pure drug ketoprofen with polymers CMC, Na alginate, hibiscus prior to the preparation of Emulgel. It indicates that no change was observed in the peak values of the drug in the physical mixture thus providing that both the drug and polymer were said to be compatible with each other. Emulgel of ketoprofen 2.5% w/w was prepared in 3 steps i.e., Preparation of gel, emulsion phases separately and incorporate both phases in homogenizer for a period of 45 min and stabilized it for 2 hrs. The prepared emulgels were evaluated for physical characteristics, drug content, pH, spreadability and in-vitro  permeation studies. The physical appearance of all the formulations was creamy white, consistent, homogenous and stable. The pH of the prepared emulgels was found well within the range of 6-7. Release rate kinetics of the drug was studied with in vitro  drug permeation data for all the formulations F1 to F9 and results were stated the best fit model for selected formulation F6 were found to be Zero order model with non-fickian diffusion. The formulations were compared with the reference product. The in-vitro dissolution of F6 was nearest to the reference product F10 (f2 = 85.17).

Keywords:

Ketoprofen, Emulgels, Homogenizer, Model Independent Approach

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Published

2021-07-13

How to Cite

Venkata Durga Seshu Priya P, Ramesh Babu K, Raja Lakshmi S, Ramya B, Navin S, Harshitha V, Rupa B, & Chandu Bhargav B. (2021). Formulation and Evaluation of Ketoprofen Emulgels by Model Independent Approach. Future Journal of Pharmaceuticals and Health Sciences, 1(3), 67–76. Retrieved from http://pharmasprings.com/index.php/fjphs/article/view/52

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Original Articles