Formulation and In-vitro Evaluation of Escitalopram Oxalate Tablets by Using Super Disintegrants

Authors

  • Voleti Vijay Kumar Department of Pharmaceutics, Santhiram College of Pharmacy, Nandyal-516501, Kurnool (Dist), Andhra Pradesh, India
  • Bharath Kumar K R S C Department of Pharmaceutics, Santhiram College of Pharmacy, Nandyal-516501, Kurnool (Dist), Andhra Pradesh, India
  • Dasthagiri Reddy Y Department of Pharmaceutics, Santhiram College of Pharmacy, Nandyal-516501, Kurnool (Dist), Andhra Pradesh, India
  • Poluri Suresh Department of Pharmaceutics, St. Johns College of Pharmaceutical Sciences, Yerrakota, Kurnool-518360, Andhra Pradesh, India
  • Naganjaneyulu R Department of Pharmacognosy, Dr K.V. Subba Reddy Institute of Pharmacy, Kurnool-518218, Andhra Pradesh, India

Abstract

Oral disintegrating Escitalopram Oxalate tablets have been formulated by direct compressing method. Escitalopram Oxalate is used as antidepressant drug and is beneficial to somebody needing dysphagia. In compatibility report there is no interaction between the drug and also the polymers. The ET1-ET9 used to be developed through direct compressing method using super disintegrants croscarmellose sodium, Hydroxypropyl Cellulose and Polacrillin potassium. All the formulations showed good flow properties. The ET9 displayed to fine results as well as varied evaluation outcomes get pleasure from Hardness, Weight variation, Disintegration time, Drug content and Dissolution profile. Stability studies were carried out with optimized formulation ET9 which was stored for a period of one and two months at 40±2OC temperature and 75±5% relative humidity for a period 2 months. There are no changes in the values up to two months, it is a stable formulations.

Keywords:

Oral Disintegrating Tablets, Escitalopram Oxalate, Direct Compression Technique, Super Disintegrants

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Published

2021-05-25

How to Cite

Voleti Vijay Kumar, Bharath Kumar K R S C, Dasthagiri Reddy Y, Poluri Suresh, & Naganjaneyulu R. (2021). Formulation and In-vitro Evaluation of Escitalopram Oxalate Tablets by Using Super Disintegrants. Future Journal of Pharmaceuticals and Health Sciences, 1(3), 27–32. Retrieved from http://pharmasprings.com/index.php/fjphs/article/view/39

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