Formulation and Evaluation of Cimetidine In-Situ Gelling System By Factorial Design
The current papers offer the formulation, optimization, and evaluation of the starch-based in-situ gelling system of Cimetidine. The objective of the present study was to optimize the concentration of starch and concentration of MgCl2 for the formulation of in-situ gels of Cimetidine. Starch based in-situ gels of Cimetidine were subjected to measurement of viscosity, pH, drug content, and Q80. Entirely the preliminary batches were prepared by using different concentrations of sodium alginate (0.5% - 2%) and a constant concentration of MgCl2. On source the preliminary Screening, a 32 full factorial pattern set about to review the consequence containing self-sustaining variables, Put concentration Containing starch (X1) and concentration containing MgCl2 (X2) as to apprenticed probabilities like viscosity, drug content, Q80, and similarity factor. The best formulation C9 exhibited optimum viscosity (316 cp), drug content (99.25%), Q80 (90.15%), and similarity factor (73.46). The best batch exhibited good water uptake (62.44%) and there were no interactions were found during the IR study. A slow release of Cimetidine was observed and a good fit to the Korsmeyer Peppas plots was demonstrated. The correlation coefficient of the best batch is 0.9973 (Korsmeyer Peppas plots).
Keywords:In-situ, Gelling System, Starch, Cimetidine, Factorial Design
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