Formulation and design of finasteride coated microneedles

Authors

  • Balakrishnan M Seshachala College of Pharmacy, Tirupathi – Chennai High way, Puttur-517 583, Chittoor (dist), Andhra Pradesh, India
  • Perumallu sudarsanam Seshachala College of Pharmacy, Tirupathi – Chennai High way, Puttur-517 583, Chittoor (dist), Andhra Pradesh, India
  • Baby shalini M Seshachala College of Pharmacy, Tirupathi – Chennai High way, Puttur-517 583, Chittoor (dist), Andhra Pradesh, India
  • Mounika K Seshachala College of Pharmacy, Tirupathi – Chennai High way, Puttur-517 583, Chittoor (dist), Andhra Pradesh, India
  • Anusha M Seshachala College of Pharmacy, Tirupathi – Chennai High way, Puttur-517 583, Chittoor (dist), Andhra Pradesh, India

Abstract

The elaborated reviews of prepared coated microneedles and their breadth of relevancy are inadequate. Cooperate with a category of medicines referred to as 5-alpha reductase inhibitors. Finasteride good things temperate prostatic hyperplasia by way of blocking the overall body's steel production going from a male hormone for which causes the overall prostate to particularize. Everything good things alopecia by way of blocking the body's production of a male hormone inside the scalp that prevents hair growth. A proportion going from alcohol found in marketed formulation the as permeation vertical stabiliser was famous to damaged hair, follicle as well as scalp epidermal polymers dehydration. The finishing line of the overall written report was once to approve the overall permeation of medicine with the aid of microneedles, thus lowering the general concentration and wear away scalp cells. Under a motic microscope, the length of uncoated microneedle and coated microneedle was found to be 634.6µ and 696.9µ precisely which either confirmed the coat over the microneedle. The percentage drug content of f6 formulation was shown at 98.80 ± 1.60 %. It encounters therefore the percentage going from drug discharge delight in coated microneedles and the marketed formulation was 96.82% and 93.93% individually. The f6 microneedle formulation encounter as far as to check zero-order release kinetics R2 value 0.737. Spectacular drug discharge analytic thinking of soaked microneedles encounter ultimate come close with the marketed solution of minoxidil of the same strength. Accelerated stability study of 30 days at accelerated temperature stipulations confirmed an insignificant speed of deterioration.

Keywords:

Microneedle, Coating, Finasteride, Microsyringe, Hair Loss

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Published

2021-01-18

How to Cite

Balakrishnan M, Perumallu sudarsanam, Baby shalini M, Mounika K, & Anusha M. (2021). Formulation and design of finasteride coated microneedles. Future Journal of Pharmaceuticals and Health Sciences, 1(1), 3–10. Retrieved from http://pharmasprings.com/index.php/fjphs/article/view/2

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Original Articles