Formulation and evaluation of Nevirapine sustained release tablets using various polymers by liquid-solid compact method

Abstract

This present research aims to formulate and evaluate the Nevirapine sustained release tablets using various polymers using a liquid-solid compact method. The current study's methodology involved comparing the two polymers, argum, and xanthumgum, and evaluating the impact of the active components' physicochemical makeup on the drug release profile utilizing the liquid solid compact method using Tween 80 and propylene glycol.The formulation is appropriate for wet granulation, according to the sieve analysis results, compressibility index, and angle of repose.According to this study, Nevirapine can be administered via an extended-release drug delivery system because its formulation prolongs its duration of action within the therapeutic range without causing toxicity as with conventional dose forms. These dosage forms provide the capacity to increase and decrease the frequency of doses.