Formulation and Evaluation of Meloxicam pH Induced In-situ Gels

Abstract

The traditional liquid ophthalmic delivery methods expose light pre-corneal residence time to come and also the better half retentivity to with the cornea which results in poor eye bioavailability. The aim of the present work was to formulate and evaluate an pH induced in situ  gels for a non steroidal anti-inflammatory drug, Meloxicam, based on the concept of pH Induced in situ gelation. The sodium alginate was used as the gelling agent in combination with HPMC (0.25- 0.75 % w/v) which means a viscosity improving agent. Compatibility studies of the drug excipients were carried out using FTIR studies. The planned out formulations have been characterised as clarity, pH, Gelation studies, drug content, In vitro drug release. In vitro release studies determined for which MF8  formulation containing 0.3%w/v of sodium and HPMC (10cps & 15cps) with 0.5%w/v each shows sustained drug release up to 8hrs & follows zero order kinetics.