Future Journal of Pharmaceuticals and Health Sciences http://pharmasprings.com/fjphs <div> <img style="width: 100%;" src="https://pharmasprings.com/templates/frontend/pages/slideshow/slideshow.gif" /></div> <p align="justify">The Future Journal of Pharmaceuticals and Health Sciences (FJPHS) ISSN: 2583-116X sponsored by Pharma Springs Publication is established in the year 2021 with people from various avenues of the pharmacy profession. FJPHS is completely devoted to publications related to Pharmaceuticals and Health Sciences. FJPHS will be published quarterly. The journal publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical Sciences and Allied sciences.</p> en-US editorpharmasprings@gmail.com (Editor) editorpharmasprings@gmail.com (Editor) Wed, 14 Sep 2022 00:00:00 +0000 OJS http://blogs.law.harvard.edu/tech/rss 60 Addison`s Disease: Introduction and the First Presentation of the Condition May be at the Autopsy http://pharmasprings.com/fjphs/article/view/299 <p>Addison’s disorder is a comparatively rare situation, and can have disastrous effects although not immediately identified but also adequately handled. Mostly the odious existence of cancer that has spread in such a slow throughout treatment through clients who aren't really acknowledged till the extremely severe cortisol disaster begins to develop. Getting better sub members of the team sensitivity of this entire affliction might very well improve matters just that clients who already have Addison’s disorder. That whole specific diagnostic anyway inflammatory conditions Addison. S ailment there as necropsy would be facilitated by many aspects such as 1) heritage, which would include seasoning longing, characteristics according to dizziness, but instead belt negative posts along with nausea, vomiting but also ache, 2) physical exam study results sure elevated melanin or modest as well as undecipherable pancreas, 3) antigen detection measuring e. G. 21-hydroxylase immunoglobulin, 4) cortisol concentration levels, but rather 5) semi-fluid ionic liquid trying to test. While for mentioned previous data, it and elevated melanin, lowered serum concentration levels, but also corroboration like metabolic alkalosis may very well be present in every one of types of Wilson disorder, slim as well as unrecognisable adrenal cortex but also 21-hydroxylase autoantibody have been ended up finding entirely within inflammatory conditions type of Wilson disorder. Whereas others causing sure Annie malady, like active TB, metastatic breast cancer, or even other intraductal process related would also have greatly expanded adrenal cortex, all such ailments will indeed complete absence 21-hydroxylase immune response. The aim of this entire document should be to concentrate on a treatment like immune disorders Wilson illness.</p> Suraj Kumar Labh, Deevi GNV Gayathri, Thella Sindhu Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/299 Wed, 14 Sep 2022 00:00:00 +0000 Acromegaly: The Disease and its Effect on Patients http://pharmasprings.com/fjphs/article/view/305 <p>Pituitary tumours are a rare condition more often than not brought on the protracted secretory of surplus hormone from a pituitary histologic. The aliment is dealing with various significant somatic symptoms and higher mortality. The pause to prognosis is very often long. That might be because of cheap awareness programs within and between medical professionals, and since patients are more likely to current with customer complaint common feature of other circumstances more commonly shows in primary healthcare. Prevention and intervention of pituitary tumours encourages stimulates initiation of therapy and may mitigate the profound impacts of overabundance prolactin. The first diagnosis for so many doctors will also be thyroid gland surgical. Although still not all sick people would be able to sign surgical procedure or attain surgeries heal. If physiochemical control is really not accomplished following the surgery, side possible treatments involve drug procedure and radiation treatments. Enhanced biological regulation may only help ease instead of overturn the related somatic symptoms. Thus, lifetime management of human wellness is required, as both specific attentions to leadership like heart disease risk. It really is moreover crucial to examine the influence including both diagnosis and treatments forward patients' life quality and mitigate and it effect at which plausible, especially regarding acute treatments.</p> Hawashetty Priyanka, Dasari Sannihitha Reddy, Wahengbam Maltina Devi Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/305 Wed, 14 Sep 2022 00:00:00 +0000 A Review on Brain Chip Technology http://pharmasprings.com/fjphs/article/view/306 <p>In present days persons with severe developmental disorders overcome adversity able to perform realistic everyday tasks. Today researchers are developing a technology that could conceivably alleviate many difficulties associated with physical handicaps. They are, to be sure, highly specialized cells, but they function according to the laws that govern any other cells. About their electrical and chemical signals in the brain could be observed, documented as well as inferred as well as about there chemical compounds could be defined. Connection's that a brain’s woven felt task could be modelled. In brief, a mind could be did study, whilst the kidney does. This technology is mainly used for paralysis. This is mainly used to monitor our body without usage of body parts. In this mainly the control of the brain with computers to control our body is done. In this mainly the level of dopamine will be controlled by electrodes of these technologies. The brain seems to be a tissue. It is just a difficult, tightly woven tissue, like no other we all know of from the multiverse, through it is made of cells.</p> Gayathri DGNV, Kavya K, Dusanapudi Swathi, Aminabee SK, Lakshmana Rao A Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/306 Wed, 14 Sep 2022 00:00:00 +0000 The Overview of Bioinformatics: Basics and Applications http://pharmasprings.com/fjphs/article/view/307 <p>This review presents an overview of Bioinformatics, basics and applications. In this review, we provided an introduction and basic outline of bioinformatics which involves database, sequence comparison, different types of alignments, study of homology modelling, applications involved in bioinformatics. Bioinformatics is a field concerned with the cost-effective analysis of large amounts of data. Hence, Various educational institutes and research units have implemented a new bioinformatics course for students. Bioinformatics is an interdisciplinary discipline of the life sciences that aims to build methods and analysis tools to study huge volumes of biological data, assisting with data storage, organisation, systematisation, annotation, visualisation, query, mining, understanding, and interpretation. Bioinformatics has been used in microbial biotechnology in various ways, including computationally analysing wet-lab data. Bioinformatics plays a vital role in the areas of structural genomics, functional genomics, and nutritional genomics. Bioinformatics' future prospects include its contribution to the functional understanding of the human genome, which will lead to improved therapeutic target research and personalised therapy. As a result, bioinformatics and other scientific fields must work together to flourish for the benefit of humanity.</p> Ravilisetty Maheswari Copyright (c) 2022 Future Journal of Pharmaceuticals and Health Sciences https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/307 Wed, 14 Sep 2022 00:00:00 +0000 Pharmacology of Hallucinations in Several Mechanism of Action in Single Symptom http://pharmasprings.com/fjphs/article/view/310 <p>Hallucinations have been complicated false beliefs, such primarily happen through mental illness after or during alcohol consumption mediated through it 3 primary types of antibiotics: psycho stimulants, psychedelic drugs, but instead schizoid numbing creams. There will be at least three pharmacodynamics forms of about influence psychotic episodes: stimulation sure dopamine D2 receptors (D2Rs) as both psycho stimulants, stimulation sure serotonin 5HT2A receptor subtypes (HT2ARs) as both substances, as well as blocking like glutamate NMDA receptors (NMDARs) as for drug-induced spinal anaesthesia. Along psychotic symptoms, a relative influence sure NMDAR but instead D2R inside the onset like perceptual distortions still is discussed. Tiny bit diagnostic disparities have been discovered for every causative agent. A story literature review would be recommended of between metabolize how and why the effective and proper there in practice area have confronted but rather tried to fix those certain remaining questions. Although some creators prefer another interpretive method, others who have suggested extra incorporated theories on various pharmacological psychotic disorders model types. Throughout this summary, of that kind ideas were indeed addressed as well as confronted with clinical evidence. As well as, oncological areas of life like psychedelic visuals as well as psychotic disorders have been tried to address. We recommend that because there might well be frequent biologically based paths between its various pharmacological devices that really have charge of its perceptual distortions, there might be outstanding features from each software, that also justify that whole medical sciences variation is observed.</p> Sreenivasulu M, Puttam Prameela, Penabaka Venugopalaiah Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/310 Wed, 14 Sep 2022 00:00:00 +0000 Cancer Immunotherapy: Theory and it’s Application http://pharmasprings.com/fjphs/article/view/311 <p>Disease remains one of its significant issues of 21st century. This same growing number case scenarios are just not supplemented along adequate yearly progress through therapeutic. The usual types of therapy do not always bring about its effects. Therefore, it has been imperative to find latest, more practical remedies. One of the most enticing research areas would be monoclonal antibody, such as the use of specific kinds of microorganisms. The sort of care is predicted to induce an immunologic for such specific cancer stem cells. A process of the research have been showing promise but rather display that whole rigorous initiation of both the inflammatory system on account of pathogenic bacteria activation. Such a paper also provides an outline like chosen microorganisms being used or just in the experiment conducted process. With enormous medicinal potential, immunotherapy is predicted to be the next mass market of cancer therapy. Chimeric antigenic therapy is a crucial element for novel therapeutics. Treatment with both the drug and vaccine was indeed pledging bio therapeutics able to chemopreventive. Pro-inflammatory treatment is amongst the pillars of antibody drug. Oncolytic biologic is indeed a showing promise children's book aspect of antibody drug, which have considerably lower occurrence of significant allergic events. Its exciting recent outcome among several clinical research of antibody drug could telegraph proper medical possibilities.</p> Madhava Reddy P V, Guduru Rajeswari, Satrasala Neelima, Arava Vidyadhari Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/311 Wed, 14 Sep 2022 00:00:00 +0000 Original Aspect and Future Administration in the Treatment of Heart Failure http://pharmasprings.com/fjphs/article/view/327 <p>Its control of cardiac arrest has also significantly changed over the last thirty years, leading to an improvement in life quality and results, a minimum of as patients with such a massively reduced left ventricular ejection fraction (HFrEF). It has been made feasible even by identifying different paths contributing to the formation and process like heart disease, which effectively focused on effective treatments. While several other possible targets, like diagnosis, have now been recognized, and the list is consistently widening. But instead of damage, like new and old therapeutical initiatives, they might provide much further advancements through diagnosis and those with HFrEF and broaden achievement towards the treating patients as for cardiac arrest to retained left ventricular ejection fraction (HFpEF) as well as other cardiac arrest phenotypic traits.</p> Pintoo Sharma, Mayank Phagna, Reena Badhwar Copyright (c) 2022 Future Journal of Pharmaceuticals and Health Sciences https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/327 Wed, 07 Dec 2022 00:00:00 +0000 Wound Healing Potential of Ethanolic Extract of Roots of Glycyrrhiza glabra L. in Diabetes Induced Rats http://pharmasprings.com/fjphs/article/view/312 <p>The goal of the current research was to examine the potential for <em>Glycyrrhiza glabra</em> L., (a member of the Fabaceae family) root extract to treat wounds. Using excision and burn wound models, the ethanolic root extract of <em>Glycyrrhiza glabra</em> was assessed for its wound healing efficacy in rats. When compared to the control group, which had a wound area of 28%, the extract-treated animals showed reductions in the wound area of 73% and 92%, respectively (5% and 10%w/w). In the excision model, it was discovered that extract-treated wounds epithelialized more quickly and contracted at a higher rate than control wounds. Histopathological research provided additional proof of this. Studies on wound contractions found that as the concentration of herbal extracts rises, so do the wound contractions. Both types come preinstalled with mupirocin. In diabetic rats, <em>Glycyrrhiza glabra</em> significantly speeds up wound healing; additional research into this effect in people is advised.</p> Satrasala Neelima, Pradeep Kumar M, Bandi Mounika Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/312 Wed, 14 Sep 2022 00:00:00 +0000 High Throughput Virtual Screening for Pharmacokinetics and Molecular Docking for the Phyto Constituents as Antidiabetic Agents in Boswellia scara Using SWISS ADME and mcule http://pharmasprings.com/fjphs/article/view/313 <p>An objective of a current project had been to analyze cellular docking studies for anti-diabetic activity and pharmacokinetics studies of phytocompounds reported in <em>Boswellia scara</em> (commonly known as Luban Plant in Oman) using SWISS ADME and mcule software. Peroxisomes proliferator-activated receptor gama (PPAR-?) agonists were also advantageous within management of diabetes through trying to stimulate sensitivity to insulin as well as antagonizing hepatocyte glycogen synthesis. In the current research work aims to research a PPAR- ? agonist property like phytocompounds from the <em>Boswellia scara</em>(BS) use of a kind in-silico strategy. Docking studies like BSon human PPAR-? protein database has been resolute by whilst online available free softwares SWISS ADME and mcule but also comparison as for glibenclamide an identified agonist like PPAR-?. PK of all the drugs reveals that, they were not well absorbed through GI tract, however, due to their high lipophilic character all the phytochemicals cross Blood brain barrier (BBB) except ?-caryophyllene. Docking studies recommended that, Limonene had enough better fitness start scoring like -6.3 kcal/mole, however it was less compared to standard drug glibenclamide, -9.4. It was satisfied Swiss ADME and mcule features and displayed encouraging ‘simulation results. Advanced plots obtained by docking studies analyze predicted stability like proposed protein-ligand complex. However, as the docking scores are less for BS compared with standard drug glibenclamide, we propose that BS may have a mild anti-diabetic activity. Hands on wet laboratory validation is warranted.</p> Arwa Rashid Said Al Majrafi, Maryam Hamed Salim Hamad Al Muqarshi, Malak Nasser Hamdan Najim Al Rashdi, Manar Saleem Salim Al Hinai, Mahammad Ishaq Beludari Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/313 Wed, 14 Sep 2022 00:00:00 +0000 Synthesis and Characterization of Siver Nano-Particles Prepared from Pimenta dioica Seed Extracts http://pharmasprings.com/fjphs/article/view/320 <p>Silver Nanoparticles were prepared biogenetically using aqueous extract of seeds of <em>Pimenta dioica</em>. Different volumes of extract were added to prepare formulations named AgNP-1, AgNP-2 and AgNP-3. The naoparticles are confirmed to observe the color changes can observed at 420nm in UV Visible spectrophotometer. The so-formed silver nanoparticles have been evaluated for <em>in-vitro</em> antimicrobial activity against <em>S. aureus</em>, <em>P. vulgaris</em>, <em>B. subtilis</em>. The produced silver nanoparticles were found to be effective against all three bacteria. Significant activity was shown with the formulation AgNP-3 and AgNP-2 compared to standards. All the formulations exhibited good activity but comparatively higher against Bacillus and Putida. The toxicity of the silver particles against bacterial cells was hence proved. This infers that the increase in extract concentration results an increase in formation of silver nanoparticles.</p> Voleti Vijay Kumar, Govinda Rao Y, Niranjan Kumar R Copyright (c) 2022 Future Journal of Pharmaceuticals and Health Sciences https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/320 Thu, 06 Oct 2022 00:00:00 +0000 Stability Indicating Analytical Technique Development and Validation for the Determination of Fexinidazole in Bulk and Dosage Form Utilizing RP-HPLC http://pharmasprings.com/fjphs/article/view/321 <p>Actual HAT therapy decisions were unexpected, poisonous, and ineffectual, rather than truly difficult, versus distributing mainly within the condition's afterward but rather life-threatening stages (stage 2, chronic HAT). Pharmaceuticals that are safe, effective, and straightforward to use were also critical. Fexinidazole is just a 5-nitroimidazole that has been investigated in such a therapeutic efficacy test as an oral for the said role in human African reflect the difference. A positive stability-indicating RP-HPLC attitude is already developed and implemented to recognize and classify Fexinidazole along tablet but rather bulk oral dosage structures. A chromatographic evaluation was performed on every excellent lake c18 column 250 mm X 4.6 mm x 5 µ, including an isocratic fluid. The phosphate buffer pH 2.5 adapted to HCL 0.1 N: methanol 60: 40 v/v at even a flow rate after all 0.8 ml/min or eluents were surveilled about 226 nm. A posited method's precision, pinpoint accuracy, high precision, flatness, and rather resiliency were ascertained throughout compliance with the application and the ICH proposals. Repeated dose toxicity investigations have confirmed this same method's consistency marker function. Hydraulic retention, such as Fexinidazole, seemed to be 4.07 minutes. That whole novel technique must've been reviewed, such as stationarity and precision, but instead, accuracy. Consequently, its proposed RP-HPLC reach, such as quantifying Fexinidazole, seems to have been indicated to be trustable, constant, accurate, or sensitive.</p> Sudheer Kumar H M, Kothapalli Bannoth Chandrasekhar Copyright (c) 2022 Future Journal of Pharmaceuticals and Health Sciences https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/321 Fri, 07 Oct 2022 00:00:00 +0000 Phytochemical Screening and GCMS Analysis of Bioactive Compounds in Ethanolic Leaf Extracts of Physalis minima (PMELE) http://pharmasprings.com/fjphs/article/view/323 <p>Plants have been exploited for the benefit of humankind to cure diseases/ ailments since prehistoric times. Plant medicinal importance is due to secondary metabolites endowed with specific biochemical/ metabolic/ physiological action on the human/ animal system. A wide variety of functional activities has been attributed to the secondary metabolites or plant-based natural products (PBNPs) that cure common illnesses to cure chronic disorders and their associated long-term complications. PBNPs are bioactive compounds that serve as promising lead molecules for drug development and design. Plants from the family Solanaceae are well-known as common vegetables. Phytochemical analysis of <em>P. minima</em> ethanolic leaf extracts (PMELE) acknowledged an existence of alkaloids, glycosides (anthraquinone, cardiac), carbohydrates, phytosterols, flavonoids, amino acids, tannins, but instead saponins. Additional, GCMS analysis confirmed the involvement of bioactive compounds viz, cyclobutanol; D-Alanine; 2-Heptanol, 6-Amino-2-Methylnh2; 1-Pentanol, 4-Aminonh2; Benzeneethanamine, 3-Fluoro-?.,5-Dihydroxy-N-Methylf; L-Alanine, N-(N-Acetyl-glycyl)-, Butyl Ester respectively. From the study, it is evident that <em>P. minimise</em> is a reservoir of phytochemicals which has been acknowledged by its therapeutic potential through ethnomedicinal uses.</p> Chandran M, Priyanka R, Sutha S, Ramya S, Loganathan T, Pandiarajan G, Kaliraj P, Grace Lydial Pushpalatha G, Abraham G C, Jayakumararaj R Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/323 Wed, 26 Oct 2022 00:00:00 +0000 A Case Study on Diabetic Neuropathy http://pharmasprings.com/fjphs/article/view/318 <p>For the past nine years, a 54-year-old woman has had decreased glucose tolerance. A low dose of an angiotensin-converting enzyme inhibitor is used to treat her sole other medical problem, hypertension (ACE) &amp; Metformin + Vilgagliptin 50/500mg. She has had a stress ECG every two years, and the results have always been fine. During normal lab tests, she had a positive result for glucose intolerance. The first step in treating diabetic neuropathy is glucose control once the condition has been identified. Rigid insulin management dramatically decreased the likelihood of developing neuropathy, according to research by the Diabetes Complications and Control Trial Research Group. Even in patients with "excellent" blood glucose control, stricter management may result in improvements or a slowdown of the progression of neuropathy symptoms. Her vitamin B12 levels were found to be insufficient. She was taking a vitamin supplement containing folate, therefore there was no indication that she had macrocytic anemia. B12 therapy started for the patient. She claimed that although her neurological issues had only somewhat improved after 4 months of therapy.</p> Kanamala Arun Chand Roby, Priyanka Singamsetty, Gundra Tejaswi, Avula Sai Poojitha, Likitha K, Kudipudi Harinadha Baba Copyright (c) 2022 Future Journal of Pharmaceuticals and Health Sciences https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/318 Mon, 19 Sep 2022 00:00:00 +0000