Future Journal of Pharmaceuticals and Health Sciences http://pharmasprings.com/fjphs <div> <img style="width: 100%;" src="https://pharmasprings.com/templates/frontend/pages/slideshow/slideshow.gif" /></div> <p align="justify">The Future Journal of Pharmaceuticals and Health Sciences (FJPHS) ISSN: 2583-116X sponsored by Pharma Springs Publication is established in the year 2021 with people from various avenues of the pharmacy profession. FJPHS is completely devoted to publications related to Pharmaceuticals and Health Sciences. FJPHS will be published quarterly. The journal publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical Sciences and Allied sciences.</p> en-US editorpharmasprings@gmail.com (Editor) editorpharmasprings@gmail.com (Editor) Wed, 15 Jun 2022 06:46:24 +0000 OJS 3.2.1.2 http://blogs.law.harvard.edu/tech/rss 60 Observational Study on Prescribing Patterns of Antihypertensive Agent and Evaluation of Comorbidities in Hypertensive Patients http://pharmasprings.com/fjphs/article/view/270 <p>Appraise the prescribing patterns of anti hypertensive agents in the treatment of hypertension and related co-morbid conditions. To assess the prescribing patterns of medications in hypertensive patients. To study the demographics of patients associated with hypertension. To compare the differences in the prescribing patterns of antihypertensive drugs, with co morbidity conditions. Review on medication outcomes in hypertensive patients. To evaluate the rationality outcomes in hypertensive patients. To obtain the mean arterial blood pressure of an individual patient. The age group 40-69 has more affected females followed by males at age group 60-79. Blood pressure increases with age, presence of the co-morbid condition, body weight, and lifestyle modification. The cause of hypertension may be known in some individuals whereas in most of the patients the cause is unknown. The individuals must be made aware of hypertension and directions about management with drugs and non-pharmacological implementation. The presence of hypertension for years may lead to further complications which if managed and monitored regularly can reduce risk. During the study period, 92 individuals were stage 1 (36.8) hypertensive followed by stage 2 (29.6%), elevated (15.2%), and normal (9.6%). The most commonly prescribed drugs in the study were Telmisartan (22.8%), Amlodipine (2.8%), Furosemide (2.4), Nifedipine (1.4), Captopril (1.4%), Metoprolol (0.8%), and Torsemide (0.8%) followed by losartan, Olmesartan, propranolol, ramipril, terlipressin, atenolol, valsartan, carvedilol, mannitol, vasopressin, and bisoprolol. Based on JNC 8 guideline the rationality of drugs obtained was 74.8%.</p> Haseena Tabassum, Bushra Unisa, Heena Fatima, Sumayya Nouras Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/270 Wed, 15 Jun 2022 00:00:00 +0000 HPTLC Method in Determination of Guggulosterone Z from Leaf Extract of Tribulus terrestris Linn http://pharmasprings.com/fjphs/article/view/271 <p>High Performance Thin Layer Chromatography (HPTLC) method is one of the best methods used in the analysis of herbal drugs. This technique is used to determine the quantity of bioactive compounds present in the extract. They have been utilized to analyze various types of natural products like alkaloids, flavonoids, steroids, terpenes, saponins, tannins etc. In this study, we have used HPTLC technique to estimate Guggulsterone Z from leaf extract of <em>Tribulus terrestris</em> Linn. In order to prepare the extracts, dry powder of <em>Tribulus terrestris</em> Linn leaves were extracted with solvent and these extracts were subjected to HPTLC analysis using mobile phase. The chromatographic plates silica gel 60F254 aluminium sheets of 20 cm x 10cm dimension were used for developing the samples. The plate was air-dried after completion of the run and observed under UV lamp. In the present research work, the results obtained determined the presence of Guggulsterone Z in <em>Tribulus terrestris</em> Linn by HPTLC method.</p> Balakrishnan M, Melapudi Krishna Reddy Manisha, Monika P S Copyright (c) 2022 Future Journal of Pharmaceuticals and Health Sciences https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/271 Wed, 15 Jun 2022 00:00:00 +0000 Design, Development and In-Vitro Characterization of Lansoprazole Delayed Release Enteric Coated Pellets in Capsules http://pharmasprings.com/fjphs/article/view/272 <p>The Current scientific work would be “Design, Progress and In-Vitro Categorization like Lansoprazole Delayed launch Capsules” indeed a categorization of proton pump inhibitor utilized during diagnosis like gastro esophagus acid reflux disease, erosional esophagitis as well as acid associated conditions. Lansoprazole would really an acid fragile opoid. That as well degrades with inside the acidic environment of it abdomen thereby resulting in therapeutic inefficacy. And thus will be essential to bypass an acidic nature of an abdomen. A current scientific task focus primarily on collection one of opoid would be Lansoprazole but also components like varied by HPC-L as well as eudragit L30 D55 have been also utilized even though enteric polymeric materials. An enteric coated granules seem to have been prepare through suspended layer-based particular method through fluidization processor. 10 compositions (F1 - F10) Lansoprazole enteric coated granules seem to have been ready wide variation a composers like drug loading, barrier coating as well as enteric covering. FT-IR has been manage to perform of about recognise this same suitability (compatibility) of some like the drug with assorted components various and SEM analysis had been done of about realize this same morphological characteristics of something like the pellets. In All 10 formulations were also maintained regarding Stability studies and done as three months there as 40°C/75 %RH but also 25°C/60 % RH as per ICH guidelines. A prepared formulations F 10 would be being shown advantageous <em>in vitro</em> acid as well as buffer release of drug in as during consistency timespan but also corresponding to a originator.</p> Boya Vivekananda, Ragsalwar Vinod, Madha Vishal, Maddhuri Chandana, Shaik Rizwan, Valluri Meghana, Santosh M Copyright (c) 2022 Future Journal of Pharmaceuticals and Health Sciences https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/272 Wed, 15 Jun 2022 00:00:00 +0000 Evaluation of In-Vitro Cytotoxic Potential of Ficus benghalensis Tender Prop Roots Extract http://pharmasprings.com/fjphs/article/view/275 <p>Cancerous cell lines might grow to develop a kind indispensible interconnect within stages through the structure–based drug to a collection of medical applicants such as cancer therapeutics. The current study is one such effort to screen for <em>in vitro</em> cytotoxic potential of methanolic prop root extract of <em>Ficus benghalensis</em> against human colon adenocarcinoma (<em>Colo 320</em>) cell cultures besides Tryphan turquoise assay as well as MTT microarrays following the 24 hours exposure. A present work demonstrated a reduction in the count of total viable cell by Tryphan blue assay. However, we have reported anti-proliferative potential of methanolic extract of <em>Ficus benghalensis</em> on colo 320 cell cultures with just an Ic50 values like 87.03µg/milliliter. Extensive research needs to be employed in the near future to explore the anti cancer potential of various solvent extracts of different parts of the plant to evolve a molecule of interest.</p> Badugu Kranti Kumar, Kondoju Arun Kumar Chary, Kiran, Gajarlu Shivani, Abdul Rahaman S K, Boidi Mamatha Copyright (c) 2022 Future Journal of Pharmaceuticals and Health Sciences https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/275 Wed, 15 Jun 2022 00:00:00 +0000 RP-HPLC Method Development and Validation for the Simultaneous Estimation of Ivermectin and Albendazole in its Pure and Combine Dosage Form http://pharmasprings.com/fjphs/article/view/280 <p>That whole percentage purification of ivermectin and albendazole seemed to be noticed of being 101.04% and 99.24% in both. That whole stability studies specifications just that Ivermectin and Albendazole also including theory trays or trying to chase aspect have been discovered of about be 4668, 1.3 and 6089 and 1.2, the resolving seemed to be discovered to also be 6.0. This same methodological approach must of been conclusively proven well according to aspect of this approach (ICH, Q2 (R1)). This same simple linear regression survey adjuvant but rather antifungal medication must have been present in concentration after all 50µg-250µg and 5µg-50µg as well as linkage coefficient (r<sup>2</sup>) has been encountered to really be 0.999 and 0.999, % regeneration had been noticed of about be 99.56% and 99.47%, %RSD regarding predictive validity had been 0.2 and 0.2, % RSD regarding medium accuracy must have been 0.2 and 0.1 respectively. It and accuracy analyze seemed to be exact, comprehensive, as well as consistent LOD value was 3.17 and 5.80, and LOQ value was 0.0172 and 0.212 respectively. Thus the posited RP-HPLC technique will be used for regimen assessment sure Ivermectin and Albendazole in API and Pharmaceutical dosage form.</p> Banothu Srikanth, Greg Maryann Nzubechuwku, Bello Munirat Omowumi, Jacintah David Kolo, Zoya Fatima Copyright (c) 2022 Future Journal of Pharmaceuticals and Health Sciences https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/280 Fri, 17 Jun 2022 00:00:00 +0000 Physicochemical Phytochemical Studies and Acute Toxicity Studies of Extract of Roots of Passiflora foetida (Passiflorine) http://pharmasprings.com/fjphs/article/view/283 <p>The Topic deal with biomedical, biological, medicinal, as well as economic features of the original substances as well as with their chemical components. The current study is one such effort to assess the physicochemical phytochemical studies and acute toxicity studies of extract of roots of <em>Passiflora foetida</em> (passiflorine). To study the antiarthritic activity of extract of roots <em>Passiflora foetida</em>. A present work demonstrated the estimation of serum SGOT (UV-Kinetic Method) and serum alkaline phosphate hydrolysis p-Nitro phenyl phosphate within presence of an oxidizing agent Mg<sup>+2</sup>. All these interaction has been assessed just like directly absorbencies proportionate to an ALP action. The Physicochemical Standards, Preliminary Phytochemical Studies and Haematological Parameter Express the values in mean ±SEM, (n=6), it when compared with the control, *P&lt;0.05, **P&lt;0.01, ***P&lt;0.001 one way ANOVA accompanied through Dunnett's t-Test. However, we perform the Effect of ethanolic extract of whole plant of <em>Passiflora foetida</em> on mean changes in paw volume as well as Biochemical parameters evaluation of ethanolic extract of root of <em>Passiflora foetida</em>.</p> Ranjit Singh B Rathor, Venkatesh P, Venkateswarlu M, Susmitha N, Rohith Sai N, Jaya Chandra N, Supriya N, Meghana Y Copyright (c) 2022 Future Journal of Pharmaceuticals and Health Sciences https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/283 Mon, 11 Jul 2022 00:00:00 +0000 Physicochemical, Phytochemical Screening and Evaluation of Antidiabetic Activity of Ficus dalhousiae Fruits on Alloxan Induced Diabetic Rats http://pharmasprings.com/fjphs/article/view/285 <p>The aim of the present study was to evaluate Physicochemical, Phytochemical Screening of Antidiabetic Activity of <em>Ficus dalhousiae</em> Fruits in Alloxan Induced Diabetic Rats. A plant material like “<em>Ficus dalhousiae</em>” member of the genus Moraceae, and physico chemical standards used for ash values. In statistical analysis, all data were represented in mean ± SEM (Standard error mean) values expressed as mean ± SEM of six samples data were analysed by one-way ANOVA followed by Dunnett's test. Effect of extracts of <em>Ficus dalhousiae</em> fruit on blood parameters against Alloxan induced Diabetic rats. The Physico-chemical standards of the fruit of <em>Ficus dalhousiae</em> have been carried out. The result shows that total Ash value was 6.7% w/w, water in soluble Ash 2.5% w/w and acid insoluble ash 0.7 w/w. Moisture content was 14.74% w/w. The water-soluble extractive values were 1.2%w/w, alcohol soluble extractive, Values 1.6% w/w and chloroform soluble extractive values were 4.6% w/v. Foaming index was 100., Fat content was 120mg, resin content was 250 mg, chloroform extract yield Was 4.3% w/w. In the present study alloxan administration induced a pronounced increase in the concentration of blood glucose and decreased glycogen in liver and muscles. A significant hyperglycaemia was attained with 24 hours after alloxan administration. The maximum effect was produced after 5 days.</p> Ranjit Singh B Rathor, Syed Muzakar, Dinakar V, Karthik D Copyright (c) 2022 Future Journal of Pharmaceuticals and Health Sciences https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/285 Sat, 16 Jul 2022 00:00:00 +0000 A Review on Hydrogel: Preparation, Characterization, and Applications http://pharmasprings.com/fjphs/article/view/273 <p>Hydrogel product lines necessitate a bunch of polymer composites; the electrophilic configuration which it’s conveys people capable of maintaining quantities of water in their three-dimensional connection. Comprehensive recruitment among these brands inside a wide range of industrial as well as environmental applications in the area is taken into account to have been of primary importance. Since intended, organic gelation have been progressively replaced besides biopolymer concept of development complete about their higher moisture absorbency, extended service existence, as well as different range like crude synthetic reserves. Poetry upon the topic must have discovered to also be widening, particularly within science fields of research. However, a number of articles as well as scientific documents handling nanogels goods from the designing viewpoints seem to be investigated versus summary technical capabilities protecting all is these rising cross-disciplinary area of research. The first goal of this headline should be to analyse a literature on topic classifying anyway alginate over separate depots, active components among these merchandise or quicker results after all about their usage. So it engaged innovations accepted recording silicone gel manufacturing along with process engineering impacts, or equilibrium data of something like the procedure. A kind created classification like previous generations sure mucoadhesive raw material has also been displayed in certain information.</p> Muppavarapu Anusha, Bijapuri Srivastava, Seelam Shyam, Prudhvi Raj V Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/273 Wed, 15 Jun 2022 00:00:00 +0000 Quality Control of the Unani System and Traditional Herbal Medicine http://pharmasprings.com/fjphs/article/view/274 <p>Traditional system of medicine have always play an important role in meeting the goal health. Traditional medicine and Natural Products have been of high significance. Those kind of systems of medicine just like Chinese medicine, ayurvedic medicine and practitioners of traditional, Korean traditional drug as well as homeopathic were practised in a few regions of the world and also have flourished into the orderly- regulatory processes of medication. Even though only one minuscule portion of the present species of plants have already been experimentally investigated for bioactive components till 1805, when first pharmacologically-active chemical codeine has been excluded through the opoid, natural ingredients as well as traditional medical already have created productive contribution for contemporary treatments. Herbal meditative substance as well as item want is continuing to increase, also with such a significantly rise inside the need; it is also very much an important necessity to preserve the standard of those. The Value of a herbal remedies seems to be modified besides variety of physical, synthetic as well as geological attributes that also help in improving the quality among these substances. Herbal system of education is one of the ancient traditional system of medicine which has strived through ages in the prevention and treatment of various medical conditions. It provide curative and rehabilitative healthcare with holistic approach.</p> Dhanshri S Nandre, Bhagyashri G Pawar, Ansari Nargis, Aejaz Ahmed, Khan G J Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/274 Wed, 15 Jun 2022 00:00:00 +0000 Gold Nanoparticles: A Review http://pharmasprings.com/fjphs/article/view/284 <p>Gold nanoparticles are small gold particles with a diameter of 1 to 100 nm. Their characteristic surface Plasmon resonance feature aid indistinctive absorption and optical properties which can be characterized and can be useful in many biomedical applications. Gold Nanoparticles can be used as delivery vectors due to their high surface loading capacity of drug, gene, Protein or vaccine. The surface of Gold Nanoparticles can be modified by molecules such as polymers, Ligands, surfactants by conjugation increases its ability to cross the membrane and also helps in reduction of cytotoxic effect due to attraction to targeted areas. So, it can be used in Targeted drug Therapy by conjugating cancer drug molecules to these particles. Gold Nanoparticles absorbs certain wavelength of incident light and converts into heat which is transferred to cancer cells and leads to destruction of cells due to photothermal effect.</p> Sujatha S, Rabbani Sk., Sai Teja P, Kishore Kumar Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ http://pharmasprings.com/fjphs/article/view/284 Mon, 11 Jul 2022 00:00:00 +0000