Future Journal of Pharmaceuticals and Health Sciences http://pharmasprings.com/fjphs <div> <img style="width: 100%;" src="https://pharmasprings.com/templates/frontend/pages/slideshow/slideshow.gif" /></div> <p align="justify">The Future Journal of Pharmaceuticals and Health Sciences (FJPHS) ISSN: 2583-116X sponsored by Pharma Springs Publication is established in the year 2021 with people from various avenues of the pharmacy profession. FJPHS is completely devoted to publications related to Pharmaceuticals and Health Sciences. FJPHS will be published quarterly. The journal publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical Sciences and Allied sciences.</p> Pharmasprings Publication en-US Future Journal of Pharmaceuticals and Health Sciences Pharmacological, Pharmacognostic and Phytochemical Review of Capparis spinosa L. http://pharmasprings.com/fjphs/article/view/99 <p>Since ancient times medicinal plants have been used as therapeutic agents for the treatment of various diseases because they possess various components that promote the health of humans with minimal side effects. WHO reveals that 80% of the world’s population depends on traditional medicine and China uses up to 50% of medicines as traditional medicine. Modern research acknowledged the importance of using various medicinal systems like , Ayurveda, and in India and also acts as the vital sources for new drugs. As global warming is showing its negative effects there may be the loss of plant productivity due to high temperatures and severe drought conditions that affect global food security. this review focused on a crop that was well adapted to severe drought and high temperatures namely Caper ( L.) The review also focuses on the recent literature on composition and pharmacological effects of Caper.</p> Archana B. Pothireddy Bharath Gundala Deepika Kiran Maheshwaram Dharani Badi Pavani Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ 2022-01-13 2022-01-13 2 1 9 21 A Review Article on Diagnostic Methods and Treatment of Co-Infection of Malaria and Typhoid http://pharmasprings.com/fjphs/article/view/104 <p>Malaria and Typhoid both are caused by parasites. Both are most common infectious diseases in throughout the world. According to WHO researches Malaria and typhoid are affected in rural and urban areas. Malaria is caused by an obligate intercellular plasmodium parasite (Plasmodium vivax, plasmodium falciparum, plasmodium malariae). Once they entered into the host erythrocytes they change their cells and structure to create an optimals for their own needs. They damage the erythrocytes structure also. According the recent researches to estimate the malaria is responsible for 1 to 3 million deaths and 300 to 500 million infectious are occurred. Annually typhoid fever is widely affected in tropical and rural areas or countries. Typhoid that is a systemic attenuated virus described by such an acute illness, the common manifestations like fever, headache, abdominal pain and leucopenia. An alliance between both the malaria and typhoid co infection was first invented or recognized in the medical literature in the middle of 19<sup>th</sup> century.</p> Gunasekharan V Venkateswarlu M Koppeti Revathi Paramjyothi Ravi Kumar Reddy Vennapusa Hemteja Reddy Ganapathi Gopinath Sai Nagineni Pavithra Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ 2022-01-13 2022-01-13 2 1 40 44 A Case Study on Exercise-Induced Acute Kidney Injury http://pharmasprings.com/fjphs/article/view/106 <p>Hypouricemia is a condition which refers to hyper-uric acid clearance due to a defect in renal tubular transport. It is considered as a hereditary renal problem. Patients with hereditary renal hypouricemia have a higher risk of exercise-induced acute kidney injury and reduced kidney function. Although avoiding exercise is considered as the best preventive measure, there are many kinds of jobs that require occupational exercise. A 32-year-old male physical trainer suffered from stage 3 Acute Kidney Injury after performing a 18-m multistage shuttle run test. His father had previously been diagnosed as having renal hypouricemia at another facility. The patient had reported having hypouricemia during a health check, but his serum uric acid concentration was within the normal range at our hospital. After treatment, he recovered from exercise-induced acute kidney injury and exhibited low serum uric acid and hyper-uric acid clearance. Since the patient desired to continue his career requiring strenuous exercise, it was difficult to propose a preventive plan against the recurrence of exercise-induced acute kidney injury. Patients suffering with hereditary renal hypouricemia are at higher risk of developing Acute Kidney Injury when undergo strenuous occupational anaerobic exercise than other workers. Hence the risks of exercise-induced acute kidney injury among patients with hypouricemia should be considered when undergoing physical occupational training.</p> Archana B Marneni Bala Sagar Kondoju Arun Kumar Chary Pagadala Kotesh Meesala Simon Ragsalwar Vinod Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ 2022-01-13 2022-01-13 2 1 1 8 Development and Characterization of Quercetin Loaded Polycaprolactone Nanoparticles for Tumors http://pharmasprings.com/fjphs/article/view/111 <p>Cancer is one of the dreadful diseases in the world, with a poor prognosis. Numerous assessments showed both tissue and cell distribution profiles of anticancer drugs might be reliant their defense in submicronic nanoparticles. The explanation behind this way is to wage increase antitumor efficacy while lowering systemic unwanted effects. These nanoparticles are well known to show theranostic activity which further increases the therapeutic index. In this study, we are developing antioxidant quercetin for the anti-tumor effect. The quercetin nanoparticles are prepared using the nanoprecipitation method with polycaprolactone as a polymer in which the nanoparticles are recovered. These nanoparticles are further optimized for the drug loading, characterized by the ­morphology using SEM and drug-polymer interactions by FT-IR, DSC. This lipophilic drug has shown a maximum entrapment efficiency of 81% and the SEM images showed nanoparticles of different shapes. There showed no interactions indicating the stability of quercetin-loaded polycaprolactone nanoparticles.</p> Sathish Banala Madhuri Reddy M Archana B Marem Laxmiprasanna Abulgsim Dudain Ali Babiker Nimmalapudi Aashritha Ollepu Keerthana Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ 2022-01-13 2022-01-13 2 1 22 28 Preparation of Colon-Targeted Avermectins Tablets and its Release Properties in vitro Studies http://pharmasprings.com/fjphs/article/view/101 <p>The purpose of the current written report sniffs out swell colon targeted drug delivery system provided that Avermectins using Eudragit L-100 and cellulose acetate phthalate. The avermectins are a sequence of drugs plus pesticides used to treat parasitic worms. Avermectins serve as unexpectedly absorbed succeeding oral administration and its half-life will be 0.5 to 2.5 hrs which may be a restriction given that Avermectins. Due to less t<sub>1/2</sub> doses of Avermectins composed grave responses within the GIT. Therefore matrix formulation involving proportions consisting of eudragit L-100 and CAP are planned out with the aid of a direct compression technique. The in-vitro drug release profile in dissolution maintain temperature at 37±0.5<sup>o</sup>C in a buffer because 19hrs. The Eudragit L-100 than by method using CAP and 1:1 ratios regarding eudragit L-100 and CAP. Succeeding 24 hrs % drug releases for the reason that AM-3 was found to be 98.2%. Drug release kinetics revealed that drug release from AM-3 tends to follow the Higuchi model along with fickian diffusion.</p> Shaik Nissar Pradeep Kumar M Chandrakala P Hari Kumar C Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ 2022-01-13 2022-01-13 2 1 29 34 Formulation and Evaluation of Fast Dissolving Oral Films of Risperidone http://pharmasprings.com/fjphs/article/view/103 <p>The current research was primarily directed to develop and implement and evaluate rapidly disintegrating Risperidone using HPMC E15 and HPMC E5. The acceptable plasticizer but also its concentration were based on the basis of flexibility, tensile strength and stickiness of a film. The films are solvent casting process. The thicknesses of the films were in the range of 0.234 mm to 0.271 mm. The weights of films have been noticed being in the range of 83 to 91. Folding endurance of films had been noticed being in the scope of 38 ± 1 to 57 ± 2. The surface PH of all films have been encountered to really be neutral since there was no change in color inside the litmus paper. The disintegration time of such ready films were all in the scope of 19 sec to 32 sec.</p> Ajith Reddy C Uma Sankar K Kishore Babu M Copyright (c) 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ 2022-01-13 2022-01-13 2 1 35 39