Formulation Development and Characterization of Glipizide Transdermal Gels by Using Permeation Enhancers

Authors

  • Venkata Durga Seshu Priya P Department of Pharmaceutics, Jagan’s Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M), Nellore-524346, SPSR Nellore (Dist), Andhra Pradesh, India http://orcid.org/0000-0002-1023-6784
  • Ramesh Babu K Department of Pharmaceutics, Swathi College of Pharmacy, NH5, Next to Nellore Toll Plaza, Venkatachalam, Nellore-524 320, SPSR Nellore (Dist), Andhra Pradesh, India
  • Bhanu Prasad Reddy B Jagan’s Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M), Nellore-524346, SPSR Nellore (Dist), Andhra Pradesh, India
  • Suresh K Jagan’s Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M), Nellore-524346, SPSR Nellore (Dist), Andhra Pradesh, India
  • Greeshma N Jagan’s Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M), Nellore-524346, SPSR Nellore (Dist), Andhra Pradesh, India
  • Madhav Jagan’s Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M), Nellore-524346, SPSR Nellore (Dist), Andhra Pradesh, India
  • Venkatesh P Jagan’s Institute of Pharmaceutical Sciences, Jangalakandriga (V), Muthukur (M), Nellore-524346, SPSR Nellore (Dist), Andhra Pradesh, India

Abstract

That in research paper an effort were made to formulate glipizide transdermal patches using different permeation enhancers. The results obtained determined the polymer and solvent victimized had an influence on drug diffusion and permeability of the films. These results obtained showed that the drug diffusion via Eudragit RLPO films was relatively high compared to Eudragit RS100 and Eudragit RL100 films(Eudragit RLPO> Eudragit RL100> Eudragit RS100). The Formulation G6 has shown a good release. The effects designated to the nonionic surfactant Tween 20 expands the permeability qualities of Glipizide when compared to the other permeation modifiers. 

Keywords:

Glipizide, Transdermal Gels, Permeation Enhancers, Permeability Coefficient

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Published

2021-10-09

How to Cite

Venkata Durga Seshu Priya P, Ramesh Babu K, Bhanu Prasad Reddy B, Suresh K, Greeshma N, Madhav, & Venkatesh P. (2021). Formulation Development and Characterization of Glipizide Transdermal Gels by Using Permeation Enhancers. Future Journal of Pharmaceuticals and Health Sciences, 1(4), 1–10. Retrieved from http://pharmasprings.com/fjphs/article/view/66

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