In vitro anti-proliferative activity of newly synthesized compounds of substituted-(3-phenyl-1,2,4-oxadiazol-5yl)-methyl-9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzocyclohepten-8-carboxylates

Authors

  • Gomedhika P M Department of Chemistry, Osmania University, Hyderabad-500 007, Telangana, India
  • Subhashini NJP Department of Chemistry, Osmania University, Hyderabad-500 007, Telangana, India

DOI:

https://doi.org/10.26452/fjphs.v2i2.237

Keywords:

American Type Culture Collection, MDA MB 231, PANC-1

Abstract

A series of the newly synthesized substituted-(3-phenyl-1,2,4-oxadiazol-5yl)-methyl-9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzocyclohepten-8-carboxylates 13a-h have been assessed for their anti-proliferative activity in vitro and shown negative effect with GI50 values 0.320-4.750 µM towards cancer cell growth. The compounds 13d, 13e, 13f, 13g showed significant activity towards three cancer cell lines of human. Among them 13 gm showed strong anti-cancer activity towards PANC-1 at 0.312 mM respectively. Notably, compound 13e showed significant activity at 0.320 mM against MDA MB-231 respectively.

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Published

2022-03-19

How to Cite

Gomedhika P M, & Subhashini NJP. (2022). In vitro anti-proliferative activity of newly synthesized compounds of substituted-(3-phenyl-1,2,4-oxadiazol-5yl)-methyl-9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzocyclohepten-8-carboxylates. Future Journal of Pharmaceuticals and Health Sciences, 2(2), 91–94. https://doi.org/10.26452/fjphs.v2i2.237

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Section

Original Articles