Formulation and Evaluation of Fast Dissolving Oral Films of Risperidone
The current research was primarily directed to develop and implement and evaluate rapidly disintegrating Risperidone using HPMC E15 and HPMC E5. The acceptable plasticizer but also its concentration were based on the basis of flexibility, tensile strength and stickiness of a film. The films are solvent casting process. The thicknesses of the films were in the range of 0.234 mm to 0.271 mm. The weights of films have been noticed being in the range of 83 to 91. Folding endurance of films had been noticed being in the scope of 38 ± 1 to 57 ± 2. The surface PH of all films have been encountered to really be neutral since there was no change in color inside the litmus paper. The disintegration time of such ready films were all in the scope of 19 sec to 32 sec.
Keywords:Fast Dissolving, Oral Films, Risperidone, In-vitro Dissolution, Disintegration
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