Preparation of Colon-Targeted Avermectins Tablets and its Release Properties in vitro Studies

Authors

  • Shaik Nissar Department of Pharmaceutical Technology, Vasavi Institute of Pharmaceutical Sciences, Vasavi Nagar, Peddapalli (V), Sidhout (M), YSR Kadapa-516 247, Andhra Pradesh, India https://orcid.org/0000-0002-2211-2228
  • Pradeep Kumar M Department of Pharmaceutical Technology, Vasavi Institute of Pharmaceutical Sciences, Vasavi Nagar, Peddapalli (V), Sidhout (M), YSR Kadapa-516 247, Andhra Pradesh, India https://orcid.org/0000-0003-3555-249X
  • Chandrakala P Department of Pharmaceutical Technology, Vasavi Institute of Pharmaceutical Sciences, Vasavi Nagar, Peddapalli (V), Sidhout (M), YSR Kadapa-516 247, Andhra Pradesh, India https://orcid.org/0000-0001-8447-119X
  • Hari Kumar C Department of Pharmacology, Vasavi Institute of Pharmaceutical Sciences, Vasavi Nagar, Peddapalli (V), Sidhout (M), YSR Kadapa-516 247, Andhra Pradesh, India https://orcid.org/0000-0003-1927-2412

Abstract

The purpose of the current written report sniffs out swell colon targeted drug delivery system provided that Avermectins using Eudragit L-100 and cellulose acetate phthalate. The avermectins are a sequence of drugs plus pesticides used to treat parasitic worms. Avermectins serve as unexpectedly absorbed succeeding oral administration and its half-life will be 0.5 to 2.5 hrs which may be a restriction given that Avermectins. Due to less t1/2 doses of Avermectins composed grave responses within the GIT. Therefore matrix formulation involving proportions consisting of eudragit L-100 and CAP are planned out with the aid of a direct compression technique. The in-vitro drug release profile in dissolution maintain temperature at 37±0.5oC in a buffer because 19hrs. The Eudragit L-100 than by method using CAP and 1:1 ratios regarding eudragit L-100 and CAP. Succeeding 24 hrs % drug releases for the reason that AM-3 was found to be 98.2%. Drug release kinetics revealed that drug release from AM-3 tends to follow the Higuchi model along with fickian diffusion.

Keywords:

Colon-Targeted Drug Delivery, Eudragit L-100, CAP, Avermectins, In-vitro Studies

Downloads

Download data is not yet available.

Published

2022-01-13

How to Cite

Shaik Nissar, Pradeep Kumar M, Chandrakala P, & Hari Kumar C. (2022). Preparation of Colon-Targeted Avermectins Tablets and its Release Properties in vitro Studies. Future Journal of Pharmaceuticals and Health Sciences, 2(1), 29–34. Retrieved from http://pharmasprings.com/fjphs/article/view/101

Issue

Section

Original Articles